6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,
"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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4
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TERMINÉ
RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,
Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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30
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TERMINÉ
Chromosome Segregation and Aneuploidy (LONGCHROM)
Date du début: 1 juin 2011, Date de fin: 31 mai 2017,
Accurate partitioning of the genetic material during cell division is critical for genetic stability. Defects in chromosome segregation produce aneuploidy, an unequal distribution of chromosomes between daughter cells, which is cause of developmental defects, and one of the cancer hallmarks. To ensure error-free transmission of chromosomes, feedback control systems verify that processes at each st ...
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1
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TERMINÉ
BBMRI - Large Prospective Cohorts (BBMRI-LPC)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,
In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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36
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TERMINÉ
Mechanism of Unconventional Protein Secretion (MUPS)
Date du début: 1 août 2011, Date de fin: 31 juil. 2016,
Approximately 30% of the human genes encode proteins that enter the Endoplasmic Reticulum (ER) by a hydrophobic sequence called the signal sequence. Most of these proteins are transported to the Golgi apparatus for sorting and subsequent delivery to the endosomes, cell surface, and the extracellular space. There is good understanding of this process of ¿conventional¿ protein secretion. Surprisingl ...
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1
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TERMINÉ
Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)
Date du début: 1 mars 2011, Date de fin: 30 juin 2016,
The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
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