3 projets européens trouvés
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TERMINÉ
Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers (EUROTRAPS)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2011,
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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TERMINÉ
European initiative to improve knowledge, treatment and survival of haemophagocytic syndromes in children (CureHLH)
Date du début: 1 juin 2008, Date de fin: 31 mai 2011,
Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening inherited immune disorder of early childhood characterised by an uncontrolled immune response. Three disease causing genes have been identified in about half of the patients. Diagnosis is difficult, pathophysiology poorly understood, and treatment unsatisfactory with about 40% of the children dying from treatment failure or t ...
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9
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TERMINÉ
Innate immunity crosstalk in immunoregulation (INNATE_CROSSTALK)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2009,
"Innate immunity is believed to protect mammalians from most infections. In the majority of cases, the quick responses by innate effector cells clear the infection before adaptive immunity develops. In recent years it has become evident that the early crosstalk between different innate immune cells also has a role in the development of adaptive immunity. In particular, NK-dendritic cell (DC) inter ...
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