8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Re-designing zinc finger proteins by swapping alpha-helical domains with foldamer helices (LXWAP)
Date du début: 11 mars 2013, Date de fin: 10 mars 2015,
"Alpha-helices (aHs) are recurrent structures in proteins, whose folding properties, stability and function have been widely investigated. They often play the key role of recognition elements between proteins, or proteins and nucleic acids. These interactions are generally regulated by the strategic presentation of a few key residues on their surface. The efforts of many groups have been devoted t ...
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2
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TERMINÉ
Dynamic Molecular Nanostructures (DYNAMOL)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,
The ITN DYNAMOL will establish a powerful new approach for the preparation of nanostructures based on dynamic covalent chemistry. This approach combines the advantages of covalent synthesis (robustness of bonds) with those of non-covalent synthesis (error correction, responsiveness) without any of the disadvantages. It therefore has the potential to provide unique solutions for several important c ...
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13
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TERMINÉ
Foldamers against protein-protein interactions (FOLDAPPI)
Date du début: 1 févr. 2009, Date de fin: 31 janv. 2014,
The Foldappi proposal aims to investigate the potential of aromatic amide Foldamers to disrupt protein-protein interactions. The scientific goals of the project include: 1. development of synthetic methods to build foldamers with different R-group chemistries 2. development of strategies to target foldamers to protein surfaces 3. measuring in vitro properties of foldamer(s) to assess ADME profile ...
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5
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TERMINÉ
An Integrated Peptide and Foldamer Chemistry Approach Towards Pro-apoptotic TRAIL Mimetics (FOLDAPOP)
Date du début: 2 mai 2011, Date de fin: 1 mai 2013,
"Death Receptors (DR), members of the tumour necrosis factor (TNF) receptor family, have come into focus as suitable targets for the selective activation of the cell death (apoptosis) pathway in tumours in vivo without causing toxicity to healthy cells. Current approaches in clinical development for replicating the function of the TNF-related apoptosis inducing ligand (TRAIL) are restricted to rec ...
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1
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TERMINÉ
Catalytic Foldamers: Engineering a Second Coordination Sphere Around a Hydrogenase Mimic (Catamers)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2013,
The protein environment that surrounds metalloenzyme active sites imparts a wide range of effects that facilitate catalysis. Supramolecular supports for homogenous catalysis may model a number of these effects. However, the use of dendrimers or polymers to provide directed second coordination sphere effects is limited by their unpredictable/unstable structures. Foldamers, based on aromatic amide u ...
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1
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TERMINÉ
Aromatic Foldamers for Single Molecule Electronics (FOSIMEL)
Date du début: 1 mars 2010, Date de fin: 29 févr. 2012,
"Recent work has demonstrated 1°) the synthetic accessibility of rigid, rod-like, helically folded aromatic amide oligomers of very large size – up to 48 units, over 12 kDa, and 7 nm long; and 2) the ability of short segments of the same oligomers to transport electrons at very fast rates via a super exchange mechanism. This project plans to investigate the potential of such unusual synthetic obje ...
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1
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TERMINÉ
AROMATIC FOLDAMERS AS DRUG DELIVERY CARRIERS (HELICAL TRANSPORTERS)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2011,
"The Huc group is a world leading research team in the fields of Biomimetic and Bioorganic Chemistry. One of group’s main contributions is focused on the synthesis, structural elucidation and biological application of aromatic oligoamides. These compounds adopt exceptionally stable folded conformations, helices, stabilised by intramolecular hydrogen bonds and - interactions. The high structural pr ...
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1
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TERMINÉ
FoldAmeRs : a new family of G-QUADruplex ligands (FAR-QUAD)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2011,
"This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy. The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines. However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase. Therefore, the use ...
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