5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Beta-cell function in juvenile diabetes and obesity (Beta-JUDO)
Date du début: 1 févr. 2012, Date de fin: 30 nov. 2016,
The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we pr ...
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12
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TERMINÉ
Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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15
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TERMINÉ
"Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy." (FIGHT-MG)
Date du début: 1 déc. 2009, Date de fin: 31 mai 2014,
"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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13
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TERMINÉ
Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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34
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TERMINÉ
Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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