3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL (MODELING MLL-AF4 ALL)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
"Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoieti ...
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TERMINÉ
Sperm chromatin and the evolution of chromatin architecture at regulatory regions in animal genomes (Evo-Chromo)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,
The genome of eukaryotic cells is packaged into chromatin. Recent technological advances have allowed the profiling of chromatin on a genome-wide scale in a diversity of living species. We are now faced with an excellent opportunity to study chromatin function and evolution in a way that was not possible before. Here, I propose to study the mechanisms of nucleosome retention in human sperm and the ...
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TERMINÉ
European Network for Genetic and Genomic Epidemiology (ENGAGE)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,
"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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