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 TERMINÉ 

Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic an ...
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 16

 TERMINÉ 

Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention ...
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 9

 TERMINÉ 

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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 17

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

 TERMINÉ 

REnaissance of Places with Innovative Citizenship and TEchnolgy (REPLICATE)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

The objective of REPLICATE is to demonstrate Smart City technologies in energy, transport and ICT in districts in San Sebastia, Florence and Bristol addressing urban complexity and generate replication plans in other districts and in follower cities of Essen,Nilufer and Lausanne.Main challenges for cities are to increase the overall energy efficiency, to exploit better local resources in terms of ...
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 37

 TERMINÉ 

Advanced Radio Astronomy in Europe (RadioNet)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

RadioNet is a consortium of 28 institutions in Europe, Republic of Korea and South Africa, integrating at European level world-class infrastructures for research in radio astronomy. These include radio telescopes, telescope arrays, data archives and the globally operating European Network for Very Long Baseline Interferometry (EVN). RadioNet is de facto widely regarded to represent the interests o ...
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 29

 TERMINÉ 

Optical Infrared Coordination Network for Astronomy (OPTICON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations ...
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 34

 TERMINÉ 

SiliconLaser (SiLAS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Our research aims to revolutionize the electronics industry by adding intra-chip and chip-to-chip communication at the speed of light, offering a significantly reduced energy consumption. Cubic crystal phase SiGe is known to be great for electronics. We propose to develop hexagonal crystal phase SiGe (Hex-SiGe) which features a direct bandgap and will add photonic capabilities to electronics. Dire ...
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 6

 TERMINÉ 

Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies (ULTRACHIRAL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing.Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are t ...
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 8

 TERMINÉ 

Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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 19

 TERMINÉ 

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 TERMINÉ 

Analytical and Characterisation Excellence in nanomaterial risk assessment: A tiered approach (ACEnano)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe dev ...
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 27

 TERMINÉ 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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 27

 TERMINÉ 

PLAtform for Climate Adaptation and Risk reDuction (PLACARD)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Significant challenges exist towards strengthening the Climate Change Adaptation (CCA) and Disaster Risk Reduction (DRR) communities for coherent, mutually reinforcing and pragmatic planning and action. PLACARD seeks to support the coordination of these two communities. PLACARD will tackle current challenges by 1) providing a common ‘space’ where CCA and DRR communities can come together, share ex ...
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 10

 TERMINÉ 

A Trans-AtLantic Assessment and deep-water ecosystem-based Spatial management plan for Europe (ATLAS)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2020,

ATLAS creates a dynamic new partnership between multinational industries, SMEs, governments and academia to assess the Atlantic’s deep-sea ecosystems and Marine Genetic Resources to create the integrated and adaptive planning products needed for sustainable Blue Growth. ATLAS will gather diverse new information on sensitive Atlantic ecosystems (incl. VMEs and EBSAs) to produce a step-change in our ...
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 24

 TERMINÉ 

A multi-center randomized, placebo-controlled trial of mirabegron, a new beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease (BETA3_LVH)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Patients with cardiovascular risk factors, e.g. hypertension and obesity are at risk of developing heart failure with preserved ejection fraction (HFpEF), a highly prevalent disease in the elderly, mostly women population. There is currently no specific, defined treatment for HFpEF, beyond control of risk factors. Activation of cardiac and vascular Beta3-adrenergic receptors (B3AR) represents a ne ...
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 15

 TERMINÉ 

BRIdges the GAp for Innovations in Disaster resilience (BRIGAID)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2020,

Recent studies from the IPCC indicate that Europe is particularly prone to increased risks of river and coastal floods, droughts resulting in water restrictions and damages from extreme weather such as heat events and wildfires. Evaluations also show a huge potential to reduce these risks with novel adaptation strategies. Researchers, innovators and incubators develop innovative products and servi ...
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 24

 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Standardization and Development of Assays for Assessment of Influenza Vaccines Correlates of Protection (FLUCOP)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Background: Influenza viruses cause annual epidemic and occasional pandemics, both of which induce significant morbidity and mortality. Influenza infections affect all age groups but children and adults over the age of 65 are at most risk of developing severe disease.Vaccination is the most effective approach to reduce the impact of annual influenza outbreaks and potential pandemics, however, the ...
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 26

 TERMINÉ 

TRANSPORT OF SOFT MATTER AT THE NANOSCALE (NANOTRANS)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

We propose a Multi-Partner ITN-ETN network on Transport of Soft Matter at the Nanoscale. The scientific topic, which is the focus of the proposal, is an emerging field of science and technology. Challenges such as design of environmentally friendly engineering materials or understanding the principles of biological organization crucially depend on fundamental understanding of transport of fluids a ...
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 10

 TERMINÉ 

European Gram Negative Antibacterial Engine (ENABLE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a ...
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 42

 TERMINÉ 

European Prevention of Alzheimer’s Dementia Consortium (EPAD)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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 40

 TERMINÉ 

PRocess-based climate sIMulation: AdVances in high resolution modelling and European climate Risk Assessment (PRIMAVERA)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

The goal of PRIMAVERA is to deliver novel, advanced and well-evaluated high-resolution global climate models (GCMs), capable of simulating and predicting regional climate with unprecedented fidelity, out to 2050. This capability will deliver innovative climate science and a new generation of advanced Earth System Models. Sector-specific end-users in policy and business will be identified and engag ...
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 19

 TERMINÉ 

Innovative multi-functional Vacuum-Insulation-Panels (VIPs) for use in the building sector (INNOVIP)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2019,

INNOVIP Consortium will reinvent the top-of-the-line insulating material vacuum-insulation-panels (VIP) by improving their thermal performance over the entire lifetime by at least 25 % and making VIPs adjustable, mountable and machineable. By reducing the density of the core material and/or using an alternative core material together with less expensive VIP-envelopes as gas barrier, it will be po ...
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 13

 TERMINÉ 

Achieving near Zero and Positive Energy Settlements in Europe using Advanced Energy Technology (ZERO-PLUS)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

"In ZERO-PLUS, a comprehensive, cost-effective system for Net Zero Energy (NZE) settlements will be developed and implemented. The system will be composed of innovative solutions for the building envelope, for building energy generation and management, and for energy management at the settlement level. A reduction of operational energy usage to an average of 0-20 kWh/m2 per year (compared with the ...
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 18

 TERMINÉ 

ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Open Digital Research Environment Toolkit for the Advancement of Mathematics (OpenDreamKit)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

OpenDreamKit will deliver a flexible toolkit enabling research groups to set up Virtual Research Environments, customised to meet the varied needs of research projects in pure mathematics and applications and supporting the full research life-cycle from exploration, through proof and publication, to archival and sharing of data and code.OpenDreamKit will be built out of a sustainable ecosystem of ...
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 17

 TERMINÉ 

Nanomaterial FAte and Speciation in the Environment (NanoFASE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

Concept: NanoFASE will deliver an integrated Exposure Assessment Framework, including methods, parameter values, model and guidance that will allow Industry to assess the full diversity of industrial nano-enabled products to a standard acceptable in regulatory registrations. Methods to assess how use phases, waste streams and environmental compartments (air, soil, water biota) act as “reactors” in ...
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 39

 TERMINÉ 

Advanced Multi-Variate Analysis for New Physics Searches at the LHC (AMVA4NewPhysics)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

With the 2012 discovery of the Higgs boson at the Large Hadron Collider, LHC, the Standard Model of particle physics has been completed, emerging as a most successful description of matter at the smallest distance scales. But as is always the case, the observation of this particle has also heralded the dawn of a new era in the field: particle physics is now turning to the mysteries posed by the pr ...
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 9

 TERMINÉ 

European Circular Energy-Frontier Collider Study (EuroCirCol)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

The award of the 2013 Nobel Prize for Physics acknowledged the leading role of Europe in particle physics, which has a global community of over 10,000 scientists. To reinforce its pole position throughout the 21st century, Europe must be ready to propose an ambitious post-LHC accelerator project by 2018/19. This is one of the main recommendations of the updated European Strategy for Particle Physi ...
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 17

 TERMINÉ 

Advanced European Infrastructures for Detectors at Accelerators (AIDA-2020)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology ...
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 38

 TERMINÉ 

Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly (CATCH ME)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF rema ...
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 9

 TERMINÉ 

High Impact Cross-section Calculations for Unprecedented Precision (HICCUP)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"The first runs of the Large Hadron Collider (LHC) experiment just finished. The LHC was successful in discovering a particle compatible with the Higgs boson of the Standard Model (SM). However expectations to discover New Physics have not been met so far.In order to establish whether the new resonance is the SM Higgs boson, or not, precise measurements of its properties are mandatory. These requi ...
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 2

 TERMINÉ 

Metrics, Models and Foresight for European Sustainable Food and Nutrition Security (SUSFANS)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,

Strengthening food and nutrition security (FNS) in the EU requires a move towards a diet that supports sustainable food consumption and production. To gauge the policy reforms needed for this major societal challenge, the SUSFANS-consortium will identify how food production and nutritional health in the EU can be aligned. The multidisciplinary research agenda of SUSFANS will build the conceptual f ...
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 17

 TERMINÉ 

Europe-Japan Accelerator Development Exchange Programme (E-JADE)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The Europe-Japan Accelerator Development Exchange Programme (E-JADE) addresses the urgent need of exchange of ideas on R&D and implementation of future accelerators for particle physics. It does so by exchanging accelerator scientists and experts between Europe and Japan.The recent European Strategy for Particle Physics and the Japanese Roadmap identify similar pressing goals of research for the n ...
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 7

 TERMINÉ 

Waves and Wave-Based Imaging in Virtual and Experimental Environments (WAVES)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Demand for highly trained scientists with a deep understanding of wave propagation in complex media, and capable of exploiting this knowledge to develop imaging tools for seismology and acoustics, is very high in the Earth and environmental sciences. Wave-based imaging serves to map spatial and temporal variations in the structure of the Earth's interior, of the oceans and atmosphere; it is used t ...
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 8

 TERMINÉ 

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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 49

 TERMINÉ 

Directed Colloidal Structure at the Meso-Scale (DiStruc)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Fluid dispersions containing highly elongated colloidal particles form a plethora of ordered, liquid-crystalline states as well as glassy and gel-like disordered states already at very low concentrations. In spite of their remarkable properties, industrial applications of such dispersions have entered the market only relatively recently, in contrast to more conventional low-molecular-weight, liqui ...
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 8

 TERMINÉ 

Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (ClickGene)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into ...
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 9