10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,
Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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12
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TERMINÉ
Blood Biomarker-based Diagnostic Tools for Early Stage Alzheimer’s Disease (BBDiag)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Alzheimer’s disease (AD) affects more than 7 million people in Europe and this figure is expected to double every 20 years. Despite intensive efforts, no disease-modifying treatments or preventive strategies are available. The lack of specific, sensitive and minimally invasive diagnostics to identify people with early-stage AD to be included in clinical drug intervention trials is among the main r ...
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13
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TERMINÉ
Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)
Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,
The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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25
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TERMINÉ
Elucidating Pathways of Steatohepatitis (EPoS)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,
Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibr ...
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13
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TERMINÉ
European Training Network on Bone Pain (BonePain)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge ...
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9
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TERMINÉ
Clinical Development of Nitisinone for Alkaptonuria (DEVELOPAKURE)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2018,
DevelopAKUre is a proposal to fund the clinical development of an orphan designated drug, nitisinone, for the treatment of a rare Mendelian disease, Alkaptonuria (AKU). AKU is a genetic deficiency of homogentisic acid dioxygenase, causing high levels of homogentisic acid (HGA). Oxidation of HGA to pigment polymer, termed ochronosis, alters connective tissues. This leads to multisystemic damage dom ...
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14
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TERMINÉ
Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases (D-BOARD)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,
"Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in jo ...
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15
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TERMINÉ
Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease (EUROCLAST)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing ...
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11
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TERMINÉ
Integrated research on DEvelopmental determinants of Aging and Longevity (IDEAL)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,
"IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.Key objectives of IDEA ...
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16
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TERMINÉ
"European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing" (EURHEALTHAGEING)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,
"Developmental plasticity modulated by epigenetic processes such as methylation and post-translational modifications is influenced by early life events and determines risk of age related diseases later in lifeWe propose a multi-disciplinary approach incorporating biochemistry, genetics, epidemiology, epigenetics and bioinformatics to discover novel biomarkers of ageing and interventional pathways ...
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