3 projets européens trouvés
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TERMINÉ
Molecular basis of the outer membrane permeability (TRANSLOCATION)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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28
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TERMINÉ
MOLECULAR BASIS OF ANTIBIOTIC TRANSLOCATION (Translocation)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Multidrug resistant bacteria are now ubiquitous in both hospitals and the larger community. Drug-resistant pathogens are becoming increasingly pervasive, for example, the resurrection of tuberculosis provides one ominous example highlighting the risk associated with evolved drug resistance. Moreover, many pharmaceutical companies abandoned this field and no truly novel active antibacterial compoun ...
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11
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TERMINÉ
Development of a new method for brief compound exposures to ion channels proteins using an automated patch clamp platform (NanionLigand)
Date du début: 15 juin 2009, Date de fin: 14 juin 2012,
The gold standard for obtaining data on ion channel function is the patch clamp method. The patch clamp technique is very labor intensive and has ultra low data throughput which has been highly motivating for the development of automated patch clamp systems.Nanion has developed a technology for performing automated patch clamp recordings on planar glass substrates, with comparable recording qualit ...
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