3 projets européens trouvés
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TERMINÉ
Arrhythmogenic potential of drugs (ARITMO)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,
The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
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21
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TERMINÉ
Safety Of non-Steroidal anti-inflammatory drugs (SOS)
Date du début: 1 nov. 2008, Date de fin: 30 avr. 2012,
"The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs). The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD an ...
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11
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TERMINÉ
Exploring and understanding adverse drug reactions by integrative mining of clinical records and biomedical knowledge (EU-ADR)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,
Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have alrea ...
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