3 projets européens trouvés
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TERMINÉ
Improving Metabolism via Prolonged Bile Acid Signalling targeting hepatic bile acid uptake to fight metabolic diseases (ProlongBileSignaling)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Bile acids play a pivotal role in energy supply as they facilitate the solubilization and absorption of fat in the intestine. Furthermore, bile acids are recently identified as important signalling molecules regulating glucose metabolism, inflammation and energy expenditure. Targeting bile acid signalling is, therefore, appealing to treat metabolic diseases such as diabetes and atherosclerosis. Th ...
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TERMINÉ
Targeting the BMP4/pSMAD/CDX-2 axis for Eradicating Barrett’s esophagus (TargetS4Barrett)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
One of the consequences of the high Socio-economical standards is the increase of diseases related to abdominal obesity, such as gastro-esophageal reflux disease. Barrett’s esophagus is a mucosal adaptation to chronic reflux disease, which is associated with an increased risk of developing esophageal adenocarcinoma. This cancer has become a significant health burden. One effective strategy to cont ...
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TERMINÉ
Targeting BMP4 and BMPR1a for imaging of esophageal adenocarcinoma (BMP4EAC)
Date du début: 1 sept. 2014, Date de fin: 29 févr. 2016,
Within BMP4EAC we aim to investigate the commercial feasibility of our newly discovered and highly specific antibodies against BMP4 and one of its receptors, BMPR1a, for imaging applications in oncology. BMP4 and BMPR1a are highly expressed in esophageal adenocarcinoma (EAC) and other tumors as well as their metastases. The specificity, strong binding capacity, rapid clearance, high tissue penetra ...
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