4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Genetic/epigenetic basis of ethnic differences in cancer predisposition (ECAP)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Integration of large scale genetic and epigenetic analysis needs to be coupled with well defined biological hypotheses that can be experimentally tested. This project is aimed at developing a novel integrated approach to understand genetic and epigenetic predisposition to cancer with skin as model system.The Caucasian (West European) and Asian (East Asian) populations differ substantially in thei ...
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1
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TERMINÉ
Development of Vascular-Disrupting Lymphocyte Therapy for Tumours (Antivessel-T-Cells)
Date du début: 1 août 2013, Date de fin: 31 juil. 2018,
T cell engineering with chimeric antigen receptors has opened the door to effective immunotherapy. CARs are fusion genes encoding receptors whose extracellular domain comprises a single chain variable fragment (scFv) antibody that binds to a tumour surface epitope, while the intracellular domain comprises the signalling module of CD3ζ along with powerful costimulatory domains (e.g. CD28 and/or 4-1 ...
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2
Participants partenaires
TERMINÉ
Inflammatory signals emerging from the endoplasmic reticulum (ERinflammation)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
The endoplasmic reticulum (ER) serves many general functions, including the facilitation of protein folding and the transport of synthesized proteins, but it also has an important and more specialized role in sensing cellular stress. ER-stress identifies a group of signals that induce a transcriptional program enabling cells to survive protein overload and injury in the ER. This highly coordinated ...
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1
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TERMINÉ
Organelle homeostasis: How are membrane fission and fusion machineries coordinated to regulate size and copy number of a lysosomal compartment? (ORGANELL)
Date du début: 1 sept. 2009, Date de fin: 31 août 2015,
Yeast vacuoles (lysosomes) will serve as an excellent model system: Vacuoles change copy number and size in the cell cycle and upon shifts of media; due to their large diameter (up to 5 µm) these changes can be assayed by fluorescence microscopy and are amenable to genetic screening. Moreover, an in vitro system for vacuole fusion exists and we recently succeeded in reconstituting also cell-free v ...
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