11 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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29
Participants partenaires
TERMINÉ
Risk of brain cancer from exposure to radiofrequency fields in childhood and adolescence (MOBI-KIDS)
Date du début: 1 mars 2009, Date de fin: 29 févr. 2016,
The rapid worldwide increase in mobile phone use in adolescents and, more recently, children has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. The current project aims to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on tumours of the central nervous system. The study ...
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18
Participants partenaires
TERMINÉ
Developmental neurotoxicity assessment of mixtures in children (DENAMIC)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. ...
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18
Participants partenaires
TERMINÉ
Mechanisms of the Development of ALLergy (MEDALL)
Date du début: 1 déc. 2010, Date de fin: 31 mai 2015,
Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
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24
Participants partenaires
TERMINÉ
Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics (Predict-IV)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2013,
The overall aim of Predict-IV is to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in-silico modelling, in a rapid and cost effective manner. A better prediction of the safety of an investigational compound in early develo ...
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20
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TERMINÉ
"Health Effects of Indoor Pollutants: Integrating microbial, toxicological and epidemiological approaches" (HITEA)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,
"Healthy housing and good indoor air quality are important goals of public health. However, biological indoor pollution due to dampness, moisture and mold is an emerging environmental health issue, as recognized in EU indoor air policy documents. Prevalence of dampness is remarkable, and may still increase due to demands of energy savings and extreme weather periods and floods associated with clim ...
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10
Participants partenaires
TERMINÉ
European Study of Cohorts for Air Pollution Effects (ESCAPE)
Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,
"European policy making is hampered by considerable uncertainty about the magnitude and nature of the impacts of long term exposure to air pollution on human health. ESCAPE is a collaboration of more than 30 European cohort studies including some 900,000 subjects. It is aimed at quantifying health impacts of air pollution and at reducing uncertainty. ESCAPE will also test new hypotheses on specifi ...
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26
Participants partenaires
TERMINÉ
Life Cycle Assessment of Environment-Compatible Flame Retardants ( Prototypical case study) (ENFIRO)
Date du début: 1 sept. 2009, Date de fin: 30 nov. 2012,
Brominated flame retardants (BFRs) will be phased out because of their environmental hazards. Less toxic alternatives appear to be available already but comprehensive information on their possible toxicological effects are lacking. ENFIRO offers a prototypical case study on substitution options for BFRs resulting in a comprehensive dataset on viability of production and application, environmental ...
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14
Participants partenaires
TERMINÉ
Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)
Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,
Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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27
Participants partenaires
TERMINÉ
Mechanisms of early protective exposures on allergy development (EFRAIM)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,
Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively inves ...
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15
Participants partenaires
TERMINÉ
ENVIRONMENTAL HEALTH RISKS IN EUROPEAN BIRTH COHORTS (ENRIECO)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2011,
"The overall aim of ENRIECO is to advance our knowledge on specific environment and health causal relationships in pregnancy and birth cohorts by providing support to exploitation of the wealth of data generated by past or ongoing studies funded by the EC and national programmes. Specific objectives are to make inventories of birth cohorts, assure quality and interoperability of exposure, health ...
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