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Chromatin Remodeling in DNA Repair: the role of the INO80 complex (INOHR)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,
The proposal aims at the study of the molecular mechanisms involved in the starting steps of the repair of the most severe type of DNA lesions, the double-stranded DNA breaks (DSBs). DSBs are caused by either environmental stress or by endogenous DNA metabolic processes. Inaccurate repair of DSBs leads to genomic instability, and thus, to cell death or cancerous malformations. Enzymes acting in DN ...
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