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12 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

European Initial Training Network on Developmental and Computational Biology (DevCom)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The ability to manipulate cellular pluripotency and differentiation holds the as yet unrealized promise of regenerative medicine to produce replacement cells and tissues. To this end a deep understanding of the regulation of differentiation potential in the context of normal embryonic development is crucial. The recent revolution in sequencing technology has enabled high throughput and genome-wide ...
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 8

 TERMINÉ 

Sarcomere based Signals in Muscle Remodelling (SARCOSI)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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 14

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

TOWARDS THE ESTABLISHMENT OF A FRAMEWORK IN MALARIA BETWEEN THE AMRN AND EVIMALAR (Ozmalnet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

54 partners from 34 institutes have formed an EC-funded Network of Excellence (NoE) in basic malaria research, the European Virtual Institute for Malaria Research (EVIMalaR). Over the previous >5 years as the NoE Biomalpar these partners successfully broke down many barriers to cooperation pursuing a programme of integrated research. This was greatly assisted by the Biomalpar PhD School whose stud ...
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 14

 TERMINÉ 

Systematic analysis and modeling of the gene regulatory network underlying neural tube patterning (Neural tube network)

Date du début: 1 mai 2011, Date de fin: 28 oct. 2013,

In many developing tissues, initially equipotent cells acquire their intended identity by exposure to extrinsic, graded signals termed morphogens, such as Sonic Hedgehog (Shh). In the ventral neural tube, Shh induces 5 progenitor domains in a precise spatial order along the dorsoventral axis of the developing spinal cord. These domains can be distinguished by the expression of different combinatio ...
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 1

 TERMINÉ 

Gene- Environment Interactions in Heart Development (CHeartED)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM inci ...
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 11

 TERMINÉ 

Intervention strategies against malaria (InterMalTraining)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

Malaria exacts a devastating social and economic cost across the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research into the biology and pathology of malaria; and AntiMal, an integrated project aiming ...
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 13

 TERMINÉ 

Signalling in life cycle stages of malaria parasites (MALSIG)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2012,

Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle o ...
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 18

 TERMINÉ 

Cis-regulatory logic of the transcriptional control in neural stem cells (CISSTEM)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM present ...
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 9

 TERMINÉ 

Coordination of patterning and growth in the developing neural tube (Pattern and growth)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2012,

Developing organs are patterned as they grow, but it is poorly understood how patterning and growth are coordinated to produce tissues of correct final proportions. In the vertebrate nervous system, neuronal type specification occurs in parallel with progenitor proliferation and differentiation. In the ventral neural tube, a Sonic hedgehog (Shh) morphogen gradient organizes the pattern of neuronal ...
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 1

 TERMINÉ 

Identification of candidate limb type identity determining genes (Limb-type ID)

Date du début: 4 janv. 2010, Date de fin: 3 janv. 2012,

Vertebrates have two pairs homologous of appendages, the forelimbs and the hindlimbs. Although these appendages are morphologically distinct, it appears that the genetic networks controlling their development act equivalently in both appendages. While the mechanisms that initiate limb outgrowth and its polarity establishment are reasonably well understood, much less is known about genes regulating ...
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 1

 TERMINÉ 

New Approaches to Target Tuberculosis (NATT)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2011,

"The increasing emergence of multidrug resistant strains and extensively drug resistant strains, the last one being virtually untreatable, urgently demand novel drugs for therapy of tuberculosis. This project has the aim of bringing together a number of research scientists with expertise in a broad range of disciplines, both from Europe and from India, covering the development field from chemistry ...
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 8