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10 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Identifying the immune and microbial network controlling the IL-22 – IL-22bp axis to open the doors for targeted therapies (IL-22 and IL-22BP)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. One hypothesis is that the same factors important for wound healing, if left unchecked, also promote tumorigenesis. Tight control by a sensor of tissue damage should induce these factors to promote tissue repair, while limiting their activity to prevent development of cancer.IL-22, a protot ...
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 2

 TERMINÉ 

Rewiring the Streptomyces cell factory for cost-effective production of biomolecules (STREPSYNTH)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

STREPSYNTH aims to set-up a Streptomyces-based new industrial production platform (SNIP) for high value added biomolecules. Streptomyces lividans was chosen as a bacterial host cell because it has been already shown to be highly efficient for the extracellular production of a number of heterologous molecules that vary chemically, has a robust tradition of industrial fermentation and is fully acces ...
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 17

 TERMINÉ 

Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection (INFECT)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presen ...
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 16

 TERMINÉ 

Interplay of inflammasomes, commensals and pathogens at mucosal interfaces (InflaComm)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1. Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensing of diverse microbial and endogenous damage-associated molecules. Recently, I discovered a novel role for the NLRP6 inflammasome in regulation of the intestinal microbio ...
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 1

 TERMINÉ 

Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PathChooser)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do ...
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 9

 TERMINÉ 

Molecular mechanisms of persistent antigenic stimulation in cytomegalovirus infection (CMVAgSTIMULUS)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2016,

Cytomegalovirus (CMV) is a ubiquitous herpesvirus, latently persisting in the majority of the adult population worldwide. In these hosts, CMV-specific memory cells dominate the immune memory compartment. It follows that CMV-specific T-cells dominate the memory compartment of the majority of the human population worldwide.I propose to define within this project the molecular mechanisms driving the ...
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 1

 TERMINÉ 

New Technologies and Production Tools for Complex Protein Biologics (ComplexINC)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines fo ...
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 8

 TERMINÉ 

Genomic predictors and oncogenic drivers in hepatocellular carcinoma (HEPTROMIC)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2014,

"Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy availab ...
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 10

 TERMINÉ 

European Network of Vaccine Development and Research (TRANSVAC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"The TRANSVAC infrastructure will accelerate the pharmaceutical and clinical development of promising vaccine candidates by bringing the gap between academic research and clinical trials through carefully managing the advancement of promising vaccine candidates from preclinical animal models to early proof-of-principle studies in humans. Although expertise already exists within Europe spanning dif ...
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 18

 TERMINÉ 

Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
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 11