Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Heart OMics in AGEing (HOMAGE)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2019,
As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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22
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TERMINÉ
Accelerated Development of Vaccine benefit-risk Collaboration in Europe (ADVANCE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Aim: The ADVANCE vision is focused on Timely and Best Evidence on Vaccine Effects. Our mission is to establish a best practice framework to rapidly provide robust data on vaccine benefits and risks to support accelerated decision-making.Approach: To achieve this vision through a public-private partnership, ADVANCE partners 1. establish common grounds and rules for collaboration between public and ...
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30
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TERMINÉ
Parasite population genomics and functional studies towards development of a blood stage malaria vaccine (GENINVADE)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
"An effective malaria vaccine is needed, particularly against P. falciparum as this species causes more human mortality than all other eukaryotic pathogens combined. An understanding of natural selection operating on parasites in local endemic populations can enable understanding of core molecular mechanisms of global relevance. The objectives are to- Advance understanding of alternative pathways ...
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5
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TERMINÉ
VPH Dementia Research Enabled by IT (VPH-DARE@IT)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,
The DementiA Research Enabled by IT project responds to the European Parliament's 2011 resolution for a European Initiative on Alzheimer's disease and other dementias, and the EU Year of the Brain 2014 Initiative. It delivers the first patient-specific predictive models for early differential diagnosis of dementias and their evolution. Its mechanistic/phenomenological models of the ageing brain ac ...
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22
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TERMINÉ
Incorporating real-life clinical data into drug development (GETREAL)
Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,
When a new medicine reaches the market, it is accompanied by an extensive data package that provides information about the safety and efficacy of the medicine in a clinical trial setting. However, assessing the expected future value of the medicines when used in “real world” clinical practice requires additional information next to traditional (pre-authorisation) clinical trials. Regulatory, HTA ...
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32
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TERMINÉ
DEVelopment Of innovative Tools for understanding marine biodiversity and assessing good Environmental Status (DEVOTES)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
The objectives are to:(i) improve our understanding of human activities impacts (cumulative, synergistic, antagonistic) and variations due to climate change on marine biodiversity, using long-term series (pelagic and benthic). This objective will identify the barriers and bottlenecks (socio-economic and legislative) that prevent the GES being achieved(ii) test the indicators proposed by the EC, an ...
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25
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TERMINÉ
NEURAL TRANSPLANTATION IN THE TREATMENT OF PATIENTS WITH PARKINSON’S DISEASE (TRANSEURO)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2016,
There are currently no cures for Parkinson's disease (PD) but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for yea ...
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15
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TERMINÉ
TRANSLATIONAL RESEARCH AND PATIENT SAFETY IN EUROPE (TRANSFoRm)
Date du début: 1 mars 2010, Date de fin: 30 nov. 2015,
TRANSFoRm will develop rigorous, generic methods for the integration of Primary Care clinical and research activities, to support patient safety and clinical research via:1.\tRich capture of clinical data, including symptoms and signs rather than just a single diagnosis. A generic, dynamic interface, integrated with electronic health records (EHR), will facilitate both diagnostic decision support ...
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25
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TERMINÉ
ICT Roadmap and Data Interoperability for Energy Systems in Smart Cities (READY4SmartCities)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2015,
READY4SmartCities operates in a European context where other initiatives are currently running in order to create a common approach on Smart Cities, Such initiatives, even if of fundamental importance for the EU, have some relevant gaps not allowing them to fully cover fundamental aspects for Smart Cities, i.e. to define a common data framework allowing full interoperability among different city s ...
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11
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TERMINÉ
Family Matters: Intergenerational Influences on Fertility (FAMMAT)
Date du début: 1 mars 2011, Date de fin: 31 août 2015,
Why do people have children? Why do they have the number of children they do? These questions are of fundamental importance, but we do not yet have satisfactory answers. I propose to bring an interdisciplinary perspective, involving demography, evolutionary biology, anthropology and psychology, to bear on this topic. The aim is to test the hypothesis that intergenerational influences are important ...
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2
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TERMINÉ
A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,
Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
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33
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TERMINÉ
Semantic Interoperability for Health Network (SemanticHealthNet)
Date du début: 1 déc. 2011, Date de fin: 31 mai 2015,
SemanticHealthNet will develop a scalable and sustainable pan-European organisational and governance process for the semantic interoperability of clinical and biomedical knowledge, to help ensure that EHR systems are optimised for patient care, public health and clinical research across healthcare systems and institutions.Through a clinically-driven workplan, exemplified in cardiovascular medicine ...
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18
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TERMINÉ
European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,
EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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15
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TERMINÉ
European large-scale functional genomics in the rat for translational research (EURATRANS)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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19
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TERMINÉ
The role of intestinal microflora in non-alcoholic fatty liver disease (NAFLD) (FLORINASH)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
As worldwide metabolic disease pandemics rise relentlessly with their concomitant clinical complications such as non alcoholic fatty liver disease, FLORINASH proposes an innovative research concept to address the role of intestinal microfloral activity in the pathogenesis of NAFLD. Firstly, to discover novel metabolic markers for the differential diagnosis and prediction of patient risk. Secondly, ...
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6
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TERMINÉ
European Study to Establish Biomarkers of Human Ageing (MARK-AGE)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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28
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TERMINÉ
RICHE – a platform and inventory for child health research in Europe (RICHE)
Date du début: 1 févr. 2010, Date de fin: 31 juil. 2013,
"The European Commission and other funding agencies make a large investment in child health research. The health of our children is satisfactory, but there are serious concerns, for example, obesity, mental health, alcohol abuse, and sexuality. We know that there are strong links between the health of young people and their social inclusion and level of education. Our objective is to establish a s ...
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27
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TERMINÉ
Bench-to-beside Integrated approach to familial hypertrophic cardiomyopathy: to the HEART of the disease (Big-Heart)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,
Hypertrophic cardiomyopathy (HCM), characterised by left ventricular hypertrophy and myocyte disarray, is by far the most common cardiac single gene disorder. With a prevalence of 1:500, HCM is predicted to affect approximately one million people within the EU. HCM represents an important clinical problem, being the principal cause of sudden death in young adults, and a valuable opportunity to use ...
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8
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TERMINÉ
Quality and safety in European Union hospitals: A research-based guide for implmeenting best practice and a framework for assessing performance (QUASER)
Date du début: 1 avr. 2010, Date de fin: 30 juin 2013,
"This translational study aims to design and disseminate an evidence based guide for hospitals to implement quality and safety improvement programmes, and an evidence based framework for payers to assess and monitor the quality and safety of hospitals across the EU. These outputs will be based on empirical findings from research in five partner countries. However, in addition, the development of t ...
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7
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TERMINÉ
European Consortium for Stem Cell Therapy for Neurodegenerative Diseases (NEuroStemCell)
Date du début: 1 déc. 2008, Date de fin: 31 mai 2013,
The NEuroStemCell consortium will foster collaboration between leading European experimental and clinical researchers in order to maximise the prospects for successful clinical trials of stem cell therapy for Parkinson's (PD) and Huntington's (HD) Disease. The activities will be driven by a Clinical WorkPackage (WP), which will set the requirements, and monitor and guide advances in development of ...
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15
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TERMINÉ
Light-based functional in vivo monitoring of diseases related enzymes (LIVIMODE)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2013,
"LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular even ...
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13
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TERMINÉ
health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries (PREHDICT)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,
"The goals of the PREHDICT study are to determine prerequisites and strategies for vaccination in European countries and to predict the impact of vaccination on screening programmes. To achieve these goals, a multiple HPV type transmission model will be built to describe the type-specific incidence and clearance of HPV infections. This model will be linked to an individual-based simulation model u ...
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14
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TERMINÉ
Genomics biomarkers of environmental health (EnviroGenomarkers)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2013,
This project concerns the first large-scale application of the full range of –omics technologies in a population study aiming at a) the discovery and validation of novel biomarkers predictive of increased risks of a number of chronic diseases, b) the exploration of the association of such biomarkers with environmental exposures, including high-priority pollutants and emerging exposures, and c) the ...
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12
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TERMINÉ
European Network for Genetic and Genomic Epidemiology (ENGAGE)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,
"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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26
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TERMINÉ
European Initiative for basic research in Microbiology and Infectious Diseases - IAPP (EIMID-IAPP)
Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,
"The EIMID-IAPP training programme is part of the European Initiative for Basic Research in Microbiology and Infectious Diseases (EIMID), created in 2003 by scientists of five European centres of excellence (the Max Planck Institute for Infection Biology in Berlin, the CMMI at Imperial College in London, the Institut Pasteur in Paris, the Karolinska Institutet in Stockholm; and the vaccine company ...
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7
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TERMINÉ
Development of cardiomyocyte replacement strategy for the clinic (CARDIOCELL)
Date du début: 1 mai 2009, Date de fin: 31 oct. 2012,
"Heart failure as a result of myocardial infarction or ischemic heart disease is a major health problem in Europe. Currently the only long term solution is heart transplantation but one in three patients die while awaiting a match. Transplantation of an alternative cell source is extremely attractive but has so far met with very little success. Thus, skeletal muscle myoblasts led to recurrent arrh ...
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7
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TERMINÉ
Multi-layer network modules to identify markers for personalized medication in complex diseases (MultiMod)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,
The symptoms of complex disease like allergy, obesity and cancer depend on the products of multiple interacting genes. High-throughput techniques have implicated hundreds of genes. There are also considerable individual variations. A clinical implication of this may be inadequate treatment response, which is increasingly recognized as a cause of increased suffering and costs. Ideally, physicians s ...
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6
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TERMINÉ
Sustaining access to Tissues and data frOm Radiobiological Experiments (STORE)
Date du début: 1 avr. 2009, Date de fin: 30 sept. 2012,
The sharing of data and biomaterials from publicly funded experimental radiation science adds enormous value to the original investment. Sharing will yield substantial scientific rewards through re-analysis and new investigations. The goal of STORE is to generate a platform that will allow the storage and retrieval of both data and the corresponding biological material from past, current and futur ...
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9
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TERMINÉ
Preclinical study of Recombinant human Anti-C5 for the Treatment of atypical HUS (PRATH)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2012,
"The Complement System is implicated in the onset, maintenance and amplification of tissue damage in several inflammatory clinical conditions. Haemolytic uraemic syndrome (HUS) is a systemic disease characterized by damage to endothelial cells and erythrocytes, thrombocytopenia, micro thrombosis and kidney failure. During the last few years it has become evident that familial atypical HUS is stron ...
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4
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TERMINÉ
Biometric European Stakeholders Network (BEST NETWORK)
Date du début: 1 oct. 2009, Date de fin: 31 mars 2012,
The main objective of BEST NETWORK is to bring together knowledge and hands-on experience with biometric deployments, addressing gaps in the gathering and dissemination of best practices, lessons learned in the scope of studies, pilots and deployments on European and Member States level.Recent experiences with biometrics-enabled systems and services have revealed issues beyond accuracy of identifi ...
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24
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TERMINÉ
Novel tools for crystallisation of macromolecules (TOPCRYST)
Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,
"The elucidation of 3-dimensional structures of proteins and other biological macromolecules and complexes is essential for rational drug design, targeting and delivery, biocatalysis, the design of environmentally friendly agrochemicals, the development of biosensors and other nanobiotechnological applications. The most powerful tool for structural analysis is X-ray crystallography, which cruciall ...
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5
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TERMINÉ
Effects of hypoxia and hypercapnia on thermoregulatory function (THERMOPHYSIO)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2012,
"Appropriate changes in skin blood flow and sweat rate are critical for humans to regulate internal temperature, especially during heat or cold stress. Limited previous research suggests that reductions in oxygen (hypoxia) and elevations in carbon dioxide (hypercapnia) concentrations affect skin blood flow and sweat rate. Up to now, however, the effects of hypoxia and hypercapnia on skin blood flo ...
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2
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TERMINÉ
European Network on Noise And Health (ENNAH)
Date du début: 1 sept. 2009, Date de fin: 31 janv. 2012,
"This proposal puts forward plans to establish a research network of experts on noise and health in Europe. This network will establish future research directions and policy needs in Europe. The network will review the existing literature on environmental noise exposure and health focussing on the consolidation of existing state of the art knowledge and the identification of gaps in the evidence a ...
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37
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TERMINÉ
"European Network for Genetic-Epidemiological Studies: building a method to dissect complex genetic traits, using essential hypertension as a disease model" (HYPERGENES)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2011,
"The project is focused on the definition of a comprehensive genetic epidemiological model of complex traits like Essential Hypertension (EH) and intermediate phenotypes of hypertension dependent/associated Target Organ Damages (TOD). To identify the common genetic variants relevant for the pathogenesis of EH and TODs, we will perform a Whole Genome Association (WGA) study of 4.000 subjects recrui ...
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19
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TERMINÉ
GENeric European Sustainable Information Space for Environment (GENESIS)
Date du début: 1 sept. 2008, Date de fin: 31 août 2011,
The GENESIS Project has the objective of providing Environment management and Health actors with an innovative solution based on advanced ICT. Relying on interoperability standards and harmonization process, GENESIS helps to constitute complex information networks, by combining benefits of various information systems with a collaborative systems approach. The proposed generic solution allows easy ...
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29
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TERMINÉ
"Trends in hospital admissions for lower extremity amputations in people with and without diabetes in England, 1996-2005" (ENG-LEA)
Date du début: 1 juin 2009, Date de fin: 31 mai 2011,
"The prevalence of diabetes mellitus is growing at epidemic proportions worldwide. Considering the steady increase of the diabetic population, the prevalence of diabetes-related complications will continue to rise. Foot disorders are a major source of morbidity and mortality and account for more hospital admissions than any other long-term complication of diabetes. Up to 20% of total expenditure o ...
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2
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TERMINÉ
Modelling the spread of pandemic influenza and strategies for its containment and mitigation (FLUMODCONT)
Date du début: 1 juin 2008, Date de fin: 31 mai 2011,
The public heath threat posed by novel strains of influenza A gaining transmissibility in people and causing a human pandemic has been recognised as potentially catastrophic, especially since the emergence and global spread of the highly pathogenic avian H5N1 virus. Several mathematical models have been developed to evaluate patterns of spatio-temporal spread of infection, and the effectiveness of ...
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11
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TERMINÉ
Intestinal dendritic cells and gut T-cell homing in inflammatory bowel diseases (Gut DCs in IBD)
Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,
Inflamatory bowel diseases (IBD) are systemic diseases characterized by intestinal inflamation and extra-intestinal manifestations. The compartimentalisation of inflammatory processes is driven by immunological mechanisms, in particular pertaining to homing and trafficking of immune cells. Intestinal Dendritic Cells (DC) are professional antigen presenting cells that recognize antigens and direct ...
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2
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TERMINÉ
VR Surgical Simulation for training: simulator design, optimisation and assessment (VRSurgicalSimulation)
Date du début: 7 sept. 2009, Date de fin: 6 sept. 2010,
The better surgeons are trained, the safer surgery procedures will be. Virtual reality (VR) surgical simulators offer new possibilities for surgeon learning, training and assessment, but they are complex to design, requiring contributions from different disciplines, such as engineering, medicine and psychology. Unfortunately, it is difficult to achieve a proper interdisciplinary communication. Mos ...
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2
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TERMINÉ
Chronic myeloid leukaemia (CML) is a disease of the haemopoietic stem cell, arising from a translocation t(9;22)(q34;q11). This translocation gives rise to a Philadelphia chromosome together with a BCR-ABL fusion gene that codes for a fusion protein with greatly enhanced tyrosine kinase activity. CML is a paradigm for the use of immunotherapy as well as being a model disease for the use of molecul ...
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