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29 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

The Economics of Mass Migration: Theory and Evidence (Migration)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The proposed research develops and tests models of individual behavior to provide evidence on the magnitude, causes and consequences of the mass migration between Europe and the US that occurred at the turn of the twentieth century. Underlying the project is the availability of electronic administrative records for 24 million migrants who arrived in the US via Ellis Island between 1892 and 1924, t ...
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 1

 TERMINÉ 

Identification, Estimation and Implementation of Structural Economic Models (Identification)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Structural economic models are getting increasingly complex. This complicates their implementation. In particular, for many models, (i) identification of the relevant components from data is still unresolved; (ii) estimation and testing procedures tend to be somewhat ad hoc and with no theoretical underpinning; (iii) the implementation of model and estimators often require numerical approximations ...
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 1

 TERMINÉ 

The Impact of Privatization on the Mortality Crisis in Eastern Europe (PrivMort)

Date du début: 1 sept. 2011, Date de fin: 31 août 2017,

After the collapse of Communism 3 to 7 million ¿excess deaths¿ occurred, comparable to the toll exacted by Stalin. While public health research has uncovered a great deal about the proximal causes of these deaths, identifying alcohol and psychosocial stress as key causes, incredibly few studies have attempted to address the variation in these proximal causes. Why did people in some countries star ...
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 4

 TERMINÉ 

DARPin Targeted Magnetic Hyperthermic Therapy for Glioblastoma (DARTRIX)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

"DARTRIX, ‘DARPin Targeted RX (therapy)’ is a multidisciplinary collaborative project that will develop high-affinity protein scaffolds to create a new generation of targeted therapeutics for the treatment of glioblastoma. There is great need; glioblastoma is virtually incurable and most patients die within 12 months of diagnosis. DARPins are small, non-immunoglobulin human protein scaffolds that ...
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 8

 TERMINÉ 

A Decision Support System incorporating a validated patient-specific, multi-scale Balance Hypermodel towards early diagnostic Evaluation and efficient Management plan formulation of Balance Disorders (EMBalance)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,

Human balance is achieved and maintained by a complex set of sensorimotor systems that include sensory input from vision, proprioception and the vestibular system (motion, equilibrium, spatial orientation); integration of the sensory input; and motor output to the muscles of the eye and body. Failure at the level of the sensory inputs or at the integration of the sensory information by the central ...
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 10

 TERMINÉ 

The genomic and transcriptomic locus of sex-specific selection in birds (Avian Dimorphism)

Date du début: 1 janv. 2011, Date de fin: 31 juil. 2016,

It has long been understood that genes contribute to phenotypes that are then the basis of selection. However, the nature and process of this relationship remains largely theoretical, and the relative contribution of change in gene expression and coding sequence to phenotypic diversification is unclear. The aim of this proposal is to fuse information about sexually dimorphic phenotypes, the mating ...
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 2

 TERMINÉ 

A phase I/IIa clinical trial in Duchenne muscular dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,

Duchenne muscular dystrophy (DMD) is a progressive, lethal muscle degenerative condition arising from the absence of dystrophin in skeletal and cardiac muscles. 65% of DMD boys have out-of-frame deletions. Modulation of pre-mRNA splicing by exon skipping is the most promising molecular intervention in DMD. 2 Phase Ib and 2 Phase IIa clinical trials (MDEX Consortium in collaboration with Sarepta Th ...
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 10

 TERMINÉ 

Rapid Identification of Respiratory Tract Infections (RID-RTI)

Date du début: 1 juil. 2012, Date de fin: 31 déc. 2015,

Respiratory Tract Infections (RTIs) are caused by a variety of bacterial, viral, fungal and other pathogens. RTIs are major causes of morbidity and mortality in adults and children worldwide causing millions of deaths each year. RTIs affecting the lung parenchyma (pneumonia) can be classified into three main categories: Community Acquired Pneumonia (CAP); Hospital Acquired Pneumonia (HAP) which in ...
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 6

 TERMINÉ 

"Morphology, Energy and Climate Change in the City" (MECHANICITY)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2015,

"Despite half a century of sustained research into the structure of cities, we still cannot answer the most basic questions of how their morphology is affected by the energy and income of their populations. We do not know if cities will become more compact or more spread out as energy usage changes due to global warming and as we switch to renewable energy sources. What we need is much more robust ...
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 1

 TERMINÉ 

Bounded Rationality in Industrial Organization (BRIO)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2014,

"Economists' modern understanding of the functioning of markets is based on the behavioral assumption of individual rationality. Market agents are assumed to hold well-defined preferences and have perfect ability to draw Bayesian inferences in accordance with correct knowledge of the market model and market equilibrium. This research proposal is based on the premise that bounded rationality on the ...
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 2

 TERMINÉ 

Long-term synaptic plasticity in interneurons: mechanisms and computational significance (InterPlasticity)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

Memory encoding occurs by strengthening or weakening of synapses among principal neurons. However, excitatory synapses on some inhibitory neurons in the hippocampus also exhibit use-dependent long-term potentiation and depression (LTP and LTD), with important consequences for network homeostasis and information processing. This proposal addresses the following areas: 1. Although the rules determin ...
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 1

 TERMINÉ 

Learning and volatility in financial markets: theory, experiments and empirics (LVFM)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2014,

The project aims to study learning and volatility in financial markets. We will develop a theoretical market microstructure model to analyze how informational inefficiencies can arise in financial markets even though traders (who have non speculative reasons to trade) are allowed to buy or sell any quantity of an asset (in a continuous action space). In this theoretical framework, we will also ana ...
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 1

 TERMINÉ 

Migration and integration of GABAergic interneurons into the developing cerebral cortex: a transgenic approach (INTERMIG)

Date du début: 1 juil. 2008, Date de fin: 31 août 2014,

Inhibitory interneurons function as modulators of local circuit excitability. Their properties are of fundamental importance for normal brain function therefore understanding how these cells are generated during development may provide insight into neurodevelopmental disorders such as epilepsy and schizophrenia, in which interneuron defects have been implicated. Inhibitory GABAergic interneurons ...
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 1

 TERMINÉ 

Computations by Neurons and Populations in Visual Cortex (CORTEX)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2014,

Neurons in primary visual cortex (area V1) receive feedforward inputs from thalamic afferents and lateral inputs from other cortical neurons. Little is known about how these components interact to determine the responses of a V1 neuron. One camp ascribes most responses to feedforward mechanisms. The other camp ascribes them mostly to lateral interactions. We propose that these two apparently opp ...
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 1

 TERMINÉ 

Game Theory and Applications in the Presence of Cognitive Limitations (GTAPCL)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

Game theory has been very successful in shaping modern economic theory over the past fifty years. Yet, the solution concepts developed under the assumption of perfect rationality require a degree of cognitive sophistication on players part that need not be realistic. In this project, I wish to broaden the definitions of equilibrium concepts to take into account the cognitive limitations of player ...
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 2

 TERMINÉ 

Exploration of strains in synthetic nanocrystals (nanosculpture)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

I plan to grow nanometre-sized crystals in confined geometries to examine the strain distributions that result. The crystal growth will employ lithographic processing techniques, made possible by the local expertise in the central clean room facilities of the London Centre for Nanotechnology. My group is world-leading in developing a method called Coherent X-ray Diffraction (CXD). Our CXD strai ...
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 1

 TERMINÉ 

How visual information is represented by neuronal networks in the primary visual cortex (Coding_in_V1)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,

The vast majority of our knowledge about how the brain encodes information has been obtained from recordings of one or few neurons at a time or from global mapping methods such as fMRI. These approaches have left unexplored how neuronal activity is distributed in space and time within a cortical column and how hundreds of neurons interact to process sensory information. By taking advantage of the ...
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 1

 TERMINÉ 

Genomic Regulatory Systems of Human X-linked neurological diseases (NeuroXsys)

Date du début: 1 juin 2009, Date de fin: 30 nov. 2012,

NeuroXsys will generate regulatory maps and models of the human X chromosome based on evolutionary conservation, with special attention to genes and regions implicated in X-linked neurological diseases. Vertebrate chromosomes are subdivided into domains of genomic regulatory blocks (GRBs) and NeuroXsys aims to map all GRBs on the X chromosome through bioinformatic approaches, extract gene regulato ...
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 9

 TERMINÉ 

Sustaining research momentum over the coming decades: mentoring the next generation of researchers for tuberculosis (TBsusgent)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

Tuberculosis is an international public health crisis of catastrophic proportions. The relative lack of TB research and funded investigators over the last several decades has been acknowledged by the The Stop TB Partnership and Global Stop TB Plan. In order to sustain research momentum over the next few decades suitably qualified investigators, who are the next generation of TB researchers, partic ...
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 7

 TERMINÉ 

Towards a fully quantum ab initio treatment of chemical reactions at solid surfaces (QUANTUMCRASS)

Date du début: 1 août 2008, Date de fin: 31 juil. 2012,

The making and breaking of bonds involving hydrogen atoms at the surfaces of materials plays a major role in nature. For example, the formation and activation of C-H, N-H, and O-H bonds lies at the heart of heterogeneous catalysis and is no less important to other disciplines such as electrochemistry and astrophysics, not to mention the widely discussed “hydrogen economy” of the future. When deali ...
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 1

 TERMINÉ 

Neuron-Glia Interactions in Nerve Development and Disease (NGIDD)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,

"The characteristic appearance of white matter in the nervous system results from a remarkable cellular structure called myelin. This membraneous sheath is wrapped around axons by dedicated glial cells, thereby allowing the rapid propagation of impulses along the axons. The importance of the myelin sheath is underscored by the many neurological diseases that are caused by loss or destabilization o ...
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 8

 TERMINÉ 

Water bodies in Europe: Integrative Systems to assess Ecological status and Recovery (WISER)

Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,

"WISER will support the implementation of the Water Framework Directive (WFD) by developing tools for the integrated assessment of the ecological status of European surface waters (with a focus on lakes and coastal/transitional waters), and by evaluating recovery processes in rivers, lakes and coastal/transitional waters under global change constraints. The project will (1) analyse existing data ...
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 26

 TERMINÉ 

Highly Accurate Breast Cancer Diagnosis through Integration of Biological Knowledge, Novel Imaging Modalities, and Modelling (HAMAM)

Date du début: 1 sept. 2008, Date de fin: 29 févr. 2012,

Despite tremendous advances in modern imaging technology, both early detection and accurate diagnosis of breast cancer are still unresolved challenges. Today, a variety of imaging modalities and image-guided biopsy procedures exist to identify and characterize morphology and function of suspicious breast tissue. However, a clinically feasible solution for breast imaging, which is both highly sensi ...
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 10

 TERMINÉ 

PAtient Specific Simulation and PreOperative Realistic Training for liver surgery (PASSPORT)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2011,

In 2006, over 45.000 European citizens died of cirrhosis of the liver and 44,000 additional citizens of liver cancer, knowing that the same year 48,700 new liver cancer cases were declared. Surgical procedures remain the options that offer the foremost success rate against such pathologies. Regretfully, surgery is not so frequent due to several limitations. Indeed, eligibility for liver surgery is ...
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 16

 TERMINÉ 

Clinically Oriented Translational Cancer Multilevel Modelling (CONTRA CANCRUM)

Date du début: 1 août 2008, Date de fin: 31 juil. 2011,

The ContraCancrum i.e. the Clinically Oriented Translational Cancer Multilevel Modelling project aims at developing a composite multilevel platform for simulating malignant tumour development and tumour and normal tissue response to therapeutic modalities and treatment schedules. The project aims at having an impact primarily in (a) the better understanding of the natural phenomenon of cancer at d ...
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 8

 TERMINÉ 

Social Insurance and Welfare-to-Work Programs: Optimal Design and Structural Evaluation (SIWTW)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2011,

This project has three main goals. First, to improve the theoretical understanding of the design of optimal social insurance and Welfare-to-Work (WTW) programs. Second, to provide a new structural framework for the evaluation of existing policies. The framework is integrated and theory-based, but rich enough to allow a meaningful empirical analysis. It specifies in detail the economic environment ...
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 2

 TERMINÉ 

Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer (O-PTM-Biomarkers)

Date du début: 1 janv. 2008, Date de fin: 31 mars 2011,

Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses ...
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 9

 TERMINÉ 

Fighting osteoporosis by blocking nucleotides: purinergic signalling in bone formation and homeostasis (ATPBone)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

"Osteoporosis is a disabling disease and the incidence is expected to increase significantly over the next decades due to an increase in the elderly population. This will lead to an enormous economical burden both in the European Union and in the rest of the world. Osteoporosis should be treated early in order to prevent the bone fractures related to the disease, and a number of anti-resorptive tr ...
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 7

 TERMINÉ 

India-Europe Cooperation to promote IPv6 adoption (6CHOICE)

Date du début: 1 mars 2008, Date de fin: 31 août 2010,

The EU and India have established an extensive Information Society dialogue. On the research side, six priority sectors were highlighted at the occasion of the last EU-India Information Society Forum: EUROINDIA 2006. Internet security, next generation mobile wireless, migration from IPv4 to IPv6, languages technologies, Open Source software and high capacity research and education network (e.g. po ...
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 8