5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Multidimensional analysis of signaling during normal hematopoietic differentiation and stress-induced regeneration (Bloody signals)
Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,
Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves sync ...
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1
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TERMINÉ
Thymopoiesis: From Evolutionary Origins to Future Therapies (EvoThyme)
Date du début: 1 juin 2013, Date de fin: 31 mai 2018,
The role of the thymus in cell-mediated immunity was discovered about 50 years ago and it has since become apparent that the thymus is the site of T cell development in all extant vertebrates. Although it has been recognized that thymopoiesis can only be fully understood by the analysis of both the thymic epithelial microenvironment and the intrathymic haematopoietic compartment, significant gaps ...
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TERMINÉ
Dissection of centromeric chromatin and components: A biosynthetic approach (BIOSYNCEN)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stability; therefore understanding centromere identity is directly relevant to cancer biology and gene therapy. How centromeres ...
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2
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TERMINÉ
Polycomb/Trithorax: Functional EpiGenomics Integrators for Metabolic Disease (MetabolicPolycombics)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
The last decade has seen an explosion of research into the epigenetic regulation of cell biology. Indeed, great efforts have been made to elucidate epigenetic regulation in stem cell biology, development, and within the plastic states of cancer. Current estimates place the prevalence of obesity in the range of 300 million to beyond 1 billion by the year 2030. As a critical risk factor for heart di ...
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1
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TERMINÉ
Dynamics and stability of covalent protein modifications (PROTMOD)
Date du début: 1 sept. 2008, Date de fin: 31 août 2014,
"One of the major goals of post-genomic biological research is to understand the molecular basis and physiological role of covalent protein modifications. Post-transcriptional modifications can regulate protein interactions and/or stability and thus trigger particular downstream responses. A major challenge is to understand how modifications of histone proteins are translated into changes in gene ...
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