9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Heart OMics in AGEing (HOMAGE)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2019,
As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
Voir le projet
22
Participants partenaires
TERMINÉ
Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
Voir le projet
19
Participants partenaires
TERMINÉ
Automation of Flow Cytometric Analysis for Quality-Assured Follow-up Assessment to Guide Curative Therapy for Acute Lymphoblastic Leukaemia in Children (AutoFlow)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
Acute Lymphoblastic Leukaemia is the most frequent leukaemia entity in children and adolescents. Despite continued progress and refinement of therapeutic approaches, disease relapse due to insufficient extinction of leukaemic blasts still remains the number one cause of treatment failure. About 15-20% of paediatric patients with the disease still suffer from relapse. Flow cytometry (FCM) is one of ...
Voir le projet
5
Participants partenaires
TERMINÉ
Personalized diagnostics and treatment of high risk coronary artery disease patients (RISKYCAD)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop ...
Voir le projet
12
Participants partenaires
TERMINÉ
Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)
Date du début: 1 oct. 2013, Date de fin: 31 mars 2017,
More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
Voir le projet
9
Participants partenaires
TERMINÉ
The Function of the RBP4 Receptor Stra6 during Retinol Saturase Regulated Adipocyte Differentiation (Stra6)
Date du début: 1 sept. 2011, Date de fin: 30 août 2016,
Obesity-related metabolic disorders such as type 2 diabetes reach epidemic proportions in most industrialized countries. Retinol binding protein 4 (RBP4), the only specific serum protein for the delivery of retinol to tissues, is increased in obesity and contributes to the development of insulin resistance and type 2 diabetes. The protein encoding stimulated by retinoic acid gene 6 (stra6) was rec ...
Voir le projet
1
Participant partenaire
TERMINÉ
The multisensory mind: From neural mechanisms to cognition (Multisensory-Mind)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
Why does food lose its taste when your nose is stuffed up? Why are we better in hearing speech when we see a speaker’s lip movements? These are questions of interest in the emerging field of multisensory integration (MI). Although the scientific study of MI on the behavioral level has existed since psychology became an experimental discipline, little is known about the precise mechanisms underlyin ...
Voir le projet
1
Participant partenaire
TERMINÉ
Vesicular glutamate transporters as molecular regulators of neural communication (SYNVGLUT)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
This proposal describes experiments aimed at defining the multiple roles of vesicular glutamate transporters (VGLUTs) in central synapses. Classically, VGLUTs transport glutamate from the cytoplasm into synaptic vesicles. Deletion of these genes disrupts synaptic glutamate release and their expression suffices to determine neurons as glutamatergic. We recently discovered that VGLUTs control additi ...
Voir le projet
1
Participant partenaire
TERMINÉ
Towards Understanding the Structure and Dynamics of Receptor Proteins (TUDOR)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
"Upon binding an agonist, the seven transmembrane (TM) helical bundle of a G-protein coupled receptor (GPCR) undergoes conformational changes that catalyze nucleotide exchange within bound G proteins. In rhodopsin, the agonist arises from light-induced isomerization of the retinal ligand, but an active conformation (Ops*) can also be adopted by the opsin apoprotein. We recently solved the structur ...
Voir le projet