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15 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

nEUROinflammation

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuroinflammation is a hallmark of multiple sclerosis and ischemic stroke. Investigating neuroinflammation as a common theme in neurological disorders, this ITN will focus in particular on myeloid cells, microglia, and endothelial cells. Sixteen partners from the academic and private sector with complementary scientific background join forces to train 13 ESRs in neuroinflammatory concepts and tech ...
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 13

 TERMINÉ 

Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders (EXTRABRAIN)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Brain disorders comprise a major burden for the society. Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases. The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics. Furthermore, ...
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 9

 TERMINÉ 

Neuroelectronics and nanotechnology: towards a Multidisciplinary Approach for the Science and Engineering of Neuronal Networks (NAMASEN)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

"We identify Neuroelectronics as a novel mature discipline, at the boundaries between neurobiology, electrophysiology, computational neurosciences, microelectronics, materials sciences, and nanotechnologies. In the proposed Marie-Curie consortium, each of these components, as well as the specific application contexts (i.e. basic research, neuroprosthetics, and pharmaceutical applications), are rep ...
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 14

 TERMINÉ 

Role of the tubulin posttranslational modifications and microtubule severing protein, katanin in the cilia central pair assembly (CP ASSEMBLY IN CILIA)

Date du début: 1 août 2011, Date de fin: 31 juil. 2015,

Cilia are microtubule (MT)-based external cell extensions that perform sensory and locomotory functions. Disruption of ciliary beating leads to human disorders such as infertility, airways diseases and hydrocephalus. The central pair of MTs (CP) apparatus is required for proper cilia motility yet the molecular mechanism that regulates its assembly is unknown. Loss of function mutations of MTs seve ...
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 1

 TERMINÉ 

BIO-IMAGing in research INnovation and Education (BIO-IMAGINE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

This Project aims at enhancing the potential of the Nencki Institute to participate actively in international research in neurobiology that uses cutting edge biological imaging techniques. Over the recent years bio-imaging has become the primary investigation method at the Institute and represents one of its strategic development areas for the next decade. A multi-level application of bio-imaging ...
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 1

 TERMINÉ 

Intelligent Knowledge Platform for Personal Health Monitoring Services (eHealthMonitor)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2014,

The eHealthMonitor project provides a platform that generates a Personal eHealth Knowledge Space (PeKS) as an aggregation of all knowledge sources (e.g., EHR and PHR) relevant for the provision of individualized personal eHealth services. This is realised by integrating service-oriented architecture, knowledge engineering, multiagent systems, and wearable/portable devices technologies. Innovations ...
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 11

 TERMINÉ 

Role of the Grhl1 gene in skin cancer (Grhl1in skin cancer)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

Many functions of the Grainyhead-like (Grhl) transcription factors have already been studied in various animal models. So far these studies have been primarily concerned with the roles of such factors in development and wound healing. Now we have new preliminary data indicating that the Grhl factors are potential novel tumor suppressors. We have already established that the Grhl1-deficient mice ha ...
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 1

 TERMINÉ 

SRF target genes in epilepsy (EpiTarGene)

Date du début: 1 juin 2009, Date de fin: 29 nov. 2013,

The aim of this project is to identify genes regulated by SRF (Serum Response Factor) in the epilepsy. Epilepsy is a chronic neurological disorder, affecting 1-3% of human population with temporal lobe epilepsy (TLE) being the most common type in adults. Unfortunately, current anti-epileptic drugs are ineffective in more than 70% of TLE patients. Therefore, it is very important to understand the m ...
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 1

 TERMINÉ 

European Study to Establish Biomarkers of Human Ageing (MARK-AGE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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 28

 TERMINÉ 

Alpha CaMKII autophosphorylation as a mechanism to regulate alcohol consumption (Alco_CaMK)

Date du début: 1 déc. 2009, Date de fin: 3 mai 2013,

Understanding molecular basis of alcohol addiction still remains a great challenge for science and at the same time the only chance for designing successful molecular therapy. Calcium and calmoduline-dependent kinase II alpha (alpha CaMKII) is a major protein of forebrain glutamatergic neurons with well established function in various aspects of cell physiology, e.g. actin remodelling. Alcohol-ind ...
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 1

 TERMINÉ 

Modulation of oligodendrocyte precursor cells differentiation fate during CNS remyelination (ModOPCFate)

Date du début: 1 oct. 2009, Date de fin: 3 mars 2013,

The aim of this project is to identify the microenviromental factors and their downstream cellular effectors determining the fate of adult CNS precursor cells which could be modulated in order to control remyelination process. Remyelination is the best example of regenerative processes in adult CNS, in which new myelin sheaths are restored to axons that have been demyelinated as a result of oligod ...
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 1

 TERMINÉ 

Promotion of plasticity as a treatment for neurodegenerative conditions (PLASTICISE)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

"Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a pr ...
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 16

 TERMINÉ 

Axonal regeneration, plasticity & stem cells (AXREGEN)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

This is a multi-disciplinary training programme focussed on the experimental and clinical problems associated with axonal damage and repair in the central nervous system. This is a central feature of a wide variety of disorders of the CNS. Future advances in this area depend on training a cohort of young researches with multiple skills. The programme encompasses ten academic and two commercial org ...
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 13

 TERMINÉ 

Promotion and facilitation of international cooperation with Eastern European and Central Asian countries (EECAlink)

Date du début: 1 juin 2009, Date de fin: 30 nov. 2011,

The EECAlink is a coordination action aimed at identification of joint research priorities of the EU and EECA countries and strengthening scientific collaboration among them. International Cooperation Partner Countries targeted by our proposal are: Armenia, Belarus, Georgia, Kazakhstan, Moldova, Russia, Ukraine and Uzbekistan. EECAlink represents (i) a measure of active encouragement of the inter ...
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 17