4 projets européens trouvés
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TERMINÉ
Parasite glycobiology and anti-parasitic strategies (GLYCOPAR)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,
"Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the pa ...
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13
Participants partenaires
TERMINÉ
Influence of the protein sequence and structure on the glycan micro-heterogeneity (GLYCAN HETEROGENEITY)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,
N-glycosylation consists in the addition of a glycan precursor onto a nascent protein in the endoplasmic reticulum. This glycan is then trimmed and matured in the Golgi by addition of various sugars motifs, leading to a large heterogeneity of glycans structures, from site to site or on the same glycosylation site. Until now the underlying causes of this micro-heterogeneity have not clearly been id ...
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1
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TERMINÉ
Systematic Isolation of Glycosyltransferases in Drosophila melanogaster Using The Toxicity of Fungal Lectins (FLYGLYGAN)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,
"Glycosyltransferases catalyze the transfer of a sugar from a glycosyl donor to an acceptor substrate and though this action are responsible for the synthesis of the vast array of glycan modifications found in nature. Identifying genes that encode proteins with glycosyltransferase activity and determining the glycan structures generated by a specific glycosyltransferase is challenging. This projec ...
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1
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TERMINÉ
Development of carbohydrate array technology to systematically explore the functional role of glycans in healthy and diseased states (EuroGlycoArrays)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
The development and production of glycoarrays will provide the foreground knowledge necessary to lead to a step change in the diagnosis and treatment of diseases ranging from cancers to autoimmune diseases. Carbohydrates play a pivotal role in the molecular interactions that govern biological events at the centre of health and disease. This has become more evident as the characterisation and ident ...
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