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15 projets européens trouvés

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 TERMINÉ 

Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is establish ...
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 2

 TERMINÉ 

Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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 3

 TERMINÉ 

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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 13

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

A TRIP through chromatin and DNA double strand break repair (TRIP)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

"Genes tend to aggregate, nucleotide usage tends to change over large domains and yet, reasons for this are poorly understood. This suggests that there exists unknown molecular processes at work for millions of years and that shape the structure of modern genomes. Understanding the organization of genomes is another way to look into these molecular processes. Particularly relevant are DNA repair ...
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 1

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease (INGENIUM)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

"The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulatio ...
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 10

 TERMINÉ 

Wnt/beta-Catenin Signalling Pathway Controls Reprogramming: The Basis Of Regeneration In Higher Vertebrates (RERE)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

Differentiation from zygotes in all cells of the body has been considered a unidirectional route. Recently, however, it has become clear that the inverse path is possible, as the reprogramming of somatic nuclei, i.e. the de-differentiation of somatic cells in pluripotent stem-like cells. To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fus ...
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 3

 TERMINÉ 

Characterization of the role of DNA methylation, hydroxymethylation and TET proteins in progesterone-mediated signaling in breast cancer cells (HydroxyMethylation)

Date du début: 13 mars 2013, Date de fin: 12 mars 2015,

Hormone-dependent cancers affect millions of people worldwide and are a great burden to society, both financially and in terms of healthcare resources. The steroid hormone progesterone plays critical roles in a variety of physiological functions as well as in the carcinogenesis of hormone-dependent cancers including breast and endometrial cancers. Progesterone regulates gene expression through his ...
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 1

 TERMINÉ 

European Consortium for Communicating Stem Cell Research (EuroStemCell)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,

The European Consortium for Communicating Stem Cell Research, EUROSTEMCELL, brings together the major current FP6 and FP7 stem cell projects, the European Clinical Research Infrastructure Network, and four internationally recognized European stem cell centres to develop a comprehensive, coordinated platform for collation, dissemination and archiving of information on stem cell biology and regenera ...
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 11

 TERMINÉ 

Regulation of coupling between transcription and splicing during cell cycle progression and UV irradiation (AS-ARK-JV-GD)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

"Alternative pre-mRNA splicing is more a rule than an exception because it is estimated to affect the expression of nearly 65%of human genes. The importance of alternative splicing (AS) is confirmed by findings that mutations that affect it are frequent in human hereditary disease and because AS factors can be misregulated in cancer. It is now well established that splicing can be cotranscriptiona ...
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 1

 TERMINÉ 

Investigating the role of p63 in PROstate STem cells and tUMOR development (p63 PROSTUMOR)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

Cancer results from genetic and epigenetic changes that cause uncontrolled proliferation of cells. Central to this process are changes in the expression of tumor suppressor genes or oncogenes. P53 is one of the best-characterized tumor suppressor genes, whose expression is lost or mutated in approximately 50% of human cancers. P63 is a member of the p53 gene family that plays critical roles in epi ...
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 1

 TERMINÉ 

Cell fusion-mediated reprogramming as neuronal rescue mechanism in Parkinson’s disease (Reprogramming for PD)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2013,

Dopamine (DA) cell replacement therapy in Parkinson’s disease (PD) can be achieved using human fetal mesencephalic tissue, however, limited tissue availability has hindered further developments. Alternatively, replacement of damaged DA neurons with their fusion with adult stem cells after bone marrow stem cells (BMSCs) transplantation is an attractive possible route to the restoration of neurologi ...
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 1

 TERMINÉ 

Regulation of epidermal stem cells by a molecular clock during tissue homeostasis and cancer (EpistemCLOCK)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2012,

Most adult tissues contain a reservoir of adult stem cells that maintain homeostasis. Loss of stem cell function can lead to severe tissue dysfunction, accelerated aging, and cancer. We study epidermal stem cells (epSCs) as a model of adult stem cell function. In steady state conditions, epSCs express high levels of ¨molecular breaks¨ that make them refractory to activating stimuli, remaining quie ...
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 2

 TERMINÉ 

Molecular mechanisms of RBM5-mediated regulation of alternative splicing: impact on cell proliferation and apoptosis (RBM5)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2012,

"Cancer diseases affect millions of people worldwide and are a source of great burden to society, both financially and in terms of health care resources. In Europe, Every day 5.214 Europeans are diagnosed with cancer and 3.185 die from their disease (20% of total cases are related to lung cancer). Understanding of how genetic factors contribute to these diseases is gathering speed. Genome-wide ass ...
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 1