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Tie2-expressing monocytes: Role in tumor angiogenesis and therapeutic targeting (Tie2+Monocytes)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,
Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis. We contributed to this concept by showing that Tie2-expressing monocytes (TEMs) have a requisite role in this process. Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models. Yet, little is known of the biological bases of TEMs activity in tumors. Building upon my prev ...
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