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22 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Exploring pericyclic reactions for bioorthogonal imaging of biological processes with molecular precision (PerBioImage)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

Bioorthogonal reactions have become essential tools for Chemical Biology and Drug Discovery. Despite recent advances in the development of bioorthogonal reactions, there still exists a need for reactions with improved kinetics and selectivities. Alkenes have been exploited in the context of site-specific protein modification and labelling, for example in cross-metathesis, photochemical 1,3-dipolar ...
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 1

 TERMINÉ 

Nutrient sensing by parasites (ParasiteNutriSensing)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its metabolism. Our preliminary data provides unequivocal evidence that Plasmodium has the ability to sense the host low-nutrient ...
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 1

 TERMINÉ 

Stromal Cell- Immune Cell Interactions in Health and Disease (STROMA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in Europe to address the key scientific questions in this emerging field. STROMA will promote the training of three Experienced Researchers (ER) and s ...
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 12

 TERMINÉ 

"""RNPnet"" - RNP structure, function and mechanism of action" (RNPNET)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and h ...
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 15

 TERMINÉ 

Differentiation of pro-inflammatory T cell subsets in vivo (T_CELL(S)_DIFFER)

Date du début: 1 déc. 2010, Date de fin: 30 juin 2015,

Our understanding of T cell differentiation impacts on vaccine development and on the treatment of (auto) immune disorders. T cells are key players in inflammation, a crucial component of the immune response to pathogens that causes severe damage to the host when uncontrolled. The cytokines Interferon-(IFN-) and Interleukin-17 (IL-17) are critical mediators of the proinflammatory activity of T ...
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 1

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

Epithelial Resealing (RESEAL)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2014,

Epithelia have the essential role of acting as a barrier that protects living organisms and its organs from the surrounding milieu. Therefore, it is crucial for epithelial tissues to have robust ways of maintaining its integrity despite the frequent damage caused by normal cell turnover, inflammation and injury. All epithelia have some capacity to repair themselves, however, the wound-healing proc ...
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 2

 TERMINÉ 

SENSE-PARK: Supporting and Empowering Parkinson patients in their home environment using a Novel SEnsory information system that monitors daily-life-relevant parameters of PARKinson disease and their (SENSE-PARK)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

Parkinson's disease (PD) is the second most common neurodegenerative disease, and prevalence increases with age. This leads, in an aging society, to increasing personal, social and economic burden. To date, basically only symptomatic treatment is available, which application almost always leads to the feeling of dependence and lose of self-control in (a) person(s) with PD (PwP's). A further shortc ...
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 7

 TERMINÉ 

Survey of tissue-specific alternative splicing in vertebrates by high-throughput sequencing: finding the elements of an evolutionary ‘splicing predictor’ (EVOALTSPLICE)

Date du début: 1 juin 2011, Date de fin: 31 mai 2014,

Splicing is a crucial aspect of gene regulation and this step in the processing of pre-mRNA to mature mRNA must occur with extreme precision to ensure that the correct message is translated by the ribosome. The coding potential and functional versatility of genes is dramatically increased by alternative splicing pathways that generate different protein isoforms, very often in a developmental stage ...
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 1

 TERMINÉ 

Chromatin and antigenic variation: The role of histone H1 in gene regulation in African trypanosomes (HistoneH1Tryp)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

Trypanosoma brucei is a unicellular parasite that causes African sleeping sickness, a fatal disease in humans. There is no vaccine and drugs are very scarce and toxic. T. brucei evades the host immune system by periodically changing its dense, uniform coat of variant surface glycoproteins (VSGs), a mechanism knows as antigenic variation. There are hundreds of VSG genes in the genome, but only one ...
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 1

 TERMINÉ 

"Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration." (MEMPEPACROSS)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,

"Peptide-lipid interactions are critical in several biomedical matters that seem uncorrelated at a first glance. MEMPEPACROSS deals with some of these: 1) Lipid membrane-interactions are the key for the understanding of dengue virus assembly and can constitute a target for its inhibition. Viral hemorrhagic fever caused by dengue virus is a serious threat to Europe, as its vector is already present ...
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 3

 TERMINÉ 

Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases (NEURASYNC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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 11

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

Toward the development of peptide-based hydrogels for tissue regeneration applications with inherent antibacterial activity (PeptideBasedHydrogel)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2012,

Hydrogels are heavily hydrated materials finding use as delivery vehicles in autologous tissue engineering. In one approach, healthy cells are first isolated from the patient and expanded in the lab. The cells are then encapsulated in a hydrogel and the resulting gel/cell construct is injected into the wound site where healing is catalyzed by the implanted cells. Although early efforts show promis ...
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 1

 TERMINÉ 

Intervention strategies against malaria (InterMalTraining)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

Malaria exacts a devastating social and economic cost across the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research into the biology and pathology of malaria; and AntiMal, an integrated project aiming ...
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 13

 TERMINÉ 

The role of EGF/ERK signaling pathway during the wound healing response in Drosophila and zebrafish epithelia (woundhealingegf)

Date du début: 1 sept. 2010, Date de fin: 31 août 2012,

Epithelia act as physical barriers that protect living organisms from the surrounding environment. Therefore, the organization and homeostasis in epithelial tissues requires robust mechanisms that assure their integrity in a variety of biological situations, such as normal cell turnover, inflammation and injury. The cell biology of wound healing has started to be understood but there are still man ...
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 1

 TERMINÉ 

Combating Antibiotics Resistant Pneumococci by Novel Strategies Based on in vivo and in vitro Host – Pathogen Interactions (CAREPNEUMO)

Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,

"The diseases caused by Streptococcus pneumoniae are a major public health problem all over the world. Children, elderly people and immuno-compromised individuals are the high-risk targets for pneumococcal diseases. In spite of the availability of a large number of antibiotics the mortality and morbidity due to S. pneumoniae infections remain very high. There are two reasons for this: Firstly, the ...
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 13

 TERMINÉ 

Elucidating the mechanism of action of cyclotides: ultra-stable proteins from plants (Cyclotide Mechanism)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,

The utility of conventional peptides in pharmaceutical and biotechnological applications is limited by their poor stability and bioavailability. Cyclotides are plant derived mini-proteins with unique structural properties that make them exceptionally stable and have a range of exciting applications in drug design and agriculture. Beside the variety of intrinsic activities, there are still many una ...
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 1

 TERMINÉ 

Réseau d'immunothérapie (IMMUNONET)

Date du début: 3 mars 2009, Date de fin: 30 déc. 2011,

El proyecto IMMUNONET se plantea como objetivo establecer una Red estable de investigación puntera en Inmunoterapia en el SUDOE con un Centro Virtual de apoyo donde distintos grupos de investigadores puedan cooperar y compartir recursos y equipamiento, e intercambiar información con universidades, administraciones públicas, la opinión pública en general y la iniciativa privada. Todos estos objetiv ...
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 9

 TERMINÉ 

The role of lipid membranes in dengue virus assembly (DENGUE VIRUS CAPSID)

Date du début: 5 juin 2009, Date de fin: 4 juin 2011,

"Viral hemorrhagic fever is a serious health threat mostly caused by the Dengue Virus (DV), which infects 50 to 100 million people worldwide yearly. Aedes spp. mosquitoes, the disease vectors endemic to tropical and subtropical regions, are spreading to temperate regions. A. aegypti, the main vector, is now found in Madeira, Portugal, and A. albopictus, a less frequent albeit potential vector, is ...
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 1

 TERMINÉ 

The function and dynamic of cholesterol during Plasmodium liver stage infection (Lipid & Infection)

Date du début: 22 avr. 2009, Date de fin: 21 avr. 2011,

Plasmodium parasites are the causative agents of malaria, amongst the most prevalent and severe human infectious diseases. Liver infection by Plasmodium sporozoites is the first obligatory step of malaria and a quite attractive target for prophylactic strategies against the disease. At this stage, each sporozoite invades a single hepatocyte and develops into thousands of merozoites that are releas ...
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 1

 TERMINÉ 

Setting the Stage in Portugal: researchers and the public come together through theatre (SettingTheStage)

Date du début: 1 mai 2009, Date de fin: 30 nov. 2009,

Through the medium of theatre and visual arts, SettingTheStage brings together research centres, universities, an SME, a science museum and theatre groups from four major cities in Portugal, to create multiple spaces where scientists and the public can actively engage in the reality of being a scientist and in the two big scientific celebrations of 2009: the 400th anniversary of Galileo's first us ...
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 9