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Most colorectal cancers (CRCs) are initiated by activating mutations in components of the Wnt signalling pathway. Physiological Wnt signals are required for the specification and maintenance of the stem and progenitor cell compartments of the intestinal crypts. We demonstrated that early colorectal lesions exhibit a constitutive Wnt target gene programme, which is very similar to that of normal in ...

"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...