6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.- (DNCure)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.-We have developed an exquisite experimental platform that facilitates the systematic unravelling of the signallingnetworks leading to (1) the initiation, (2) the progression and (3) the potential regeneration of podocytes inDN, paving the way to novel therapeutic strategies:(1) DN initiation: Identifi ...
Voir le projet
1
Participant partenaire
TERMINÉ
The lysine-specific demethylase1 (LSD1) in physiology and pathology (LSD1)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,
"The identification of the first histone demethylase lysine-specific demethylase 1 (LSD1) established not only the concept of reversible histone methylation in epigenetic regulation but also translated this fundamentally novel biological observation into understanding the molecular mechanisms regulation stemness, differentiation, proliferation, and pathological growth. To unravel in an unbiased an ...
Voir le projet
1
Participant partenaire
TERMINÉ
Molecular basis of the outer membrane permeability (TRANSLOCATION)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
Voir le projet
28
Participants partenaires
TERMINÉ
Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus (PathCO)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected per ...
Voir le projet
11
Participants partenaires
TERMINÉ
Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle (ODIN)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Vitamin D deficiency has significant implications for human health and impacts on healthy growth and development and successful aging. Fundamental knowledge gaps are barriers to implementing a safe and effective public health strategy to prevent vitamin D deficiency and optimize status. ODIN will provide the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health ...
Voir le projet
32
Participants partenaires
TERMINÉ
A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)
Date du début: 1 août 2013, Date de fin: 31 juil. 2016,
Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
Voir le projet