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18 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

3D structures of bacterial supramolecular assemblies by solid-state NMR (assemblyNMR)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Supramolecular assemblies – formed by the self-assembly of hundreds of protein subunits – are part of bacterial nanomachines involved in key cellular processes. Important examples in pathogenic bacteria are pili and type 3 secretion systems (T3SS) that mediate adhesion to host cells and injection of virulence proteins. Structure determination at atomic resolution of such assemblies by standard tec ...
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 2

 TERMINÉ 

Mechanisms of chromosome segregation in mammalian oocytes (CHROMOOCYTE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

All animal life starts with the fertilization of an egg. A haploid egg and a haploid sperm fuse and together they form a new genetically unique embryo. But surprisingly, eggs frequently contain an incorrect number of chromosomes. Depending on the age of the woman, 10-50% of eggs are chromosomally abnormal. This high percentage of abnormal eggs results from chromosome segregation errors during oocy ...
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 2

 TERMINÉ 

The nanomechanical mechanism of exocytotic fusion pore formation (The Fusion Machine)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

Cells release neurotransmitters, hormones and other compounds stored in secretory vesicles by a process called exocytosis. In this process, the molecules are released upon stimulation by a nanomachine forming a fusion pore that connects the vesicular lumen to the extracellular space. Similar fusion events are also essential for intracellular transport mechanisms and virus-induced fusion.Here I pro ...
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 1

 TERMINÉ 

New magnetic resonance techniques to determine the dynamic structure of mitochondrial outer membrane proteins and their complexes (DYNAMOM)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

Membrane proteins are coded by about 30% of the genes in the human genome and are primary targets for the action of drugs. I propose an interdisciplinary approach that will provide insight into the dynamic structure of membrane proteins of the outer mitochondrial membrane at unprecedented detail with respect to spatial resolution and time scale separation. Analysis of the dynamics and structure of ...
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 2

 TERMINÉ 

Mechanism of Regulated Transcription Initiation (TRANSIT)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,

"The regulation of gene transcription governs eukaryotic cell growth and differentiation. Despite its importance, transcription regulation is not understood at a mechanistic level. Regulation occurs mainly during initiation, when the enzyme RNA polymerase II (Pol II) assembles with ~50 polypeptides on promoter DNA. Regulatory signals are transmitted by the 25-subunit Mediator, and convert the init ...
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 2

 TERMINÉ 

HER Imaging and Molecular Interaction Mapping in Breast Cancer (IMAGINT)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2015,

The aim is to develop tools for imaging and characterising protein/protein and protein/RNA interactions in cancer using Designed Ankyrin Repeat Proteins (DARPins). DARPins are small, ultrahighly stable, antibody-like proteins that bind specific targets with high affinity in monovalent form and are readily engineered for site-specific chemical modification. The exemplar protein family will be EGFR, ...
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 11

 TERMINÉ 

TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases (TREATPOLYQ)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Protein aggregation is a hallmark of many late onset neurodegenerative disorders including Parkinson’s Disease (PD), Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), prion diseases as well as the group of polyglutamine diseases (polyQ). The aim of this proposal is to create a network of European partners bridging important basic mechanisms involved in proteinopathies, research of mod ...
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 17

 TERMINÉ 

NMR for Structural Biology (Bio-NMR)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dyna ...
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 20

 TERMINÉ 

NMR detected nanosecond to microsecond dynamics for biomolecular recognition dynamics (hiddentimeNMR)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2014,

NMR spectroscopy detects in a unique way with atomic resolution biomolecular dynamics in the previously hidden time range between approximately 5 nano- to 50 microseconds (ns-ms time range). The detection of this motion happens in equilibrium under physiological conditions without the need for a triggering reaction. On the example of ubiquitin, this dynamics was found by us to be important for mol ...
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 2

 TERMINÉ 

Intravital optical super-resolution imaging in the brain (brain STED)

Date du début: 1 juin 2012, Date de fin: 31 mai 2014,

Synapses are small, highly specialized structures of intercellular contact that play a crucial role in neuronal information processing and memory. While traditional fluorescence microscopy is an extremely powerful tool to study the dynamics of biological processes in vivo with molecular specificity, it has insufficient resolving power to dissect details of synaptic structure and functional organiz ...
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 1

 TERMINÉ 

Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases (NEURASYNC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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 11

 TERMINÉ 

Detection of membrane-interacting cytotoxic amyloid intermediates with novel fluorescent probes (Detectamyloid)

Date du début: 1 juil. 2010, Date de fin: 5 sept. 2012,

Formation and deposition of fibrillar protein aggregates (amyloids) is a fundamental feature of neurodegenerative diseases. It has been suggested that neurotoxicity in Parkinson’s disease originates from the binding of α-synuclein (AS) oligomers to cellular membranes, resulting in bilayer disruption and leakage. Membrane binding is also presumed to be involved in the (as yet unknown) physiological ...
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 2

 TERMINÉ 

Structural Biology of Membrane Proteins (SBMPs)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

Membrane proteins (MPs) are known to be key molecules in cellular communications, from signal transduction to transport of ions, metabolites and other molecules. They also participate in the synthesis of ATP, the import of soluble or MPs from the cytosol, and they protect living organisms from toxic factors. The proposal consists in a joint training effort involving the major biophysical methods t ...
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 12

 TERMINÉ 

Investigation of the voltage-dependent anion channel 2 (VDAC2) by solid-state NMR and molecular dynamic simulations (VDAC2)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2012,

"Voltage-dependent anion channels (VDACs) are pore-forming proteins expressed in the outer membrane of eukaryotic mitochondria. The three isoforms of VDAC, i.e., VDAC1, VDAC2 and VDAC3, are known to be expressed ubiquitously in mammalian mitochondria. The individual VDAC isoforms (VDAC1 and VDAC2) are considered to play different roles in the induction of apoptosis through Bcl-2 family proteins an ...
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 2

 TERMINÉ 

Ultra-high resolution and ultra-sensitive fluorescence methods for objective sub-cellular diagnosis of early disease and disease progression in breast and prostate cancer (FLUODIAMON)

Date du début: 1 juin 2008, Date de fin: 31 mai 2012,

"The overall objective of this proposal is to develop and validate a quantitative, minimally invasive diagnostic tool for early and conclusive detection, diagnosis and monitoring of disease and disease progression of breast and prostate cancer. A methodology will be developed making use of a combination of the probably most exciting recent advances in the field of light microscopy, for fluorescenc ...
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 12

 TERMINÉ 

Determination of molecular dynamics in membrane proteins and protein fibrils using novel solid-state NMR methods (DYNAMIC PROTEINS)

Date du début: 1 sept. 2008, Date de fin: 31 août 2010,

"Structural data obtained from X-ray crystallography as well as from NMR spectroscopy has clearly provided evidences that many proteins have intrinsic disorder either locally or globally. Emerging evidence suggests that these small or large-scale deformations occur at various time scales and provide important hints for the regulatory mechanisms of the proteins. In this view protein plasticity is b ...
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 2

 TERMINÉ 

Smart nondimensional biosensors for detection of tumor cells and cytotoxic amyloids intermediates (NANOSMARTS)

Date du début: 1 sept. 2008, Date de fin: 31 août 2010,

"This project integrates the development of (a) bioconjugated silicon nanoparticles (NPs) as new, < 3nm, fluorescent probes and (b) dual-emission band fluorescent biosensors for protein conformation investigations to be applied in diagnostic procedures related to tumor biology and neurodegenerative diseases. Epidermal growth factor receptor (EGFR) is an important therapeutic target in a variety of ...
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 2

 TERMINÉ 

Analyzing Heterogeneity in Release of Synaptic Vesicles (WIERDA-HETEROGENEITY)

Date du début: 1 août 2008, Date de fin: 31 juil. 2009,

"Recent studies in the Calyx of Held, a specialized synapse in the auditory pathway, have now produced clear evidence of heterogeneity in release-‘willingness’ among releasable vesicles. The general aim of this project is to investigate heterogeneity of release willingness in typical CNS synapses and to characterize the molecular mechanisms that control this heterogeneity. We will first develop ...
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 2