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27 projets européens trouvés

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 TERMINÉ 

Electronic Health Record systems for Clinical Research (EHR4CR)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

Current medical needs, the growth of targeted therapies and personalized medicines, and escalating R&D costs result in formidable cost pressures on healthcare systems and the pharmaceutical industry. Clinical research is also growing in complexity, labour intensity and cost. There is a growing realization that the development and integration of Electronic Health Record systems (EHRs) for medical ...
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 37

 TERMINÉ 

European Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS (EuroCoord)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
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 26

 TERMINÉ 

Cutaneous and Mucosal HIV Vaccination (CUT'HIVAC)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cel ...
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 18

 TERMINÉ 

European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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 15

 TERMINÉ 

Scalable, Standard based Interoperability Framework for Sustainable Pro-active Post Market Safety Studies (SALUS)

Date du début: 1 févr. 2012, Date de fin: 30 avr. 2015,

Pre-approval clinical trials cannot possibly ensure that a drug will not have disastrous side effects once it arrives on the market. Post-approval safety data gathering was put in place to address this problem, but as implemented, it has not proven to be as effective as hoped. This is due to the fact that, current post market safety studies largely depend on the submission of spontaneous case repo ...
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 10

 TERMINÉ 

Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT)

Date du début: 1 sept. 2009, Date de fin: 30 avr. 2015,

Recent pharmacovigilance (PV) issues have led to questions regarding the ability of the current PV system to meet the global needs. Controversies around the assessment of spontaneous reports and conflicting results from pharmacoepidemiology studies may lead to delay in, or inappropriate, regulatory decisions. The PROTECT consortium, consisting of 20 core partners lead by the European Medicines Age ...
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 36

 TERMINÉ 

European large-scale functional genomics in the rat for translational research (EURATRANS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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 19

 TERMINÉ 

Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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 22

 TERMINÉ 

Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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 19

 TERMINÉ 

THE GLUCO- AND MINERALO-CORTICOID PATHWAYS IN RETINA: MOLECULAR CARACTERISATION AND THERAPEUTIC IMPLICATION (GlucoMineraloRet)

Date du début: 1 mai 2011, Date de fin: 24 déc. 2014,

Considering the alarming rate of diabetic patients becoming blind after retinal edema formation, and the important risks of ocular complications due to the low specificity of the current glucocorticoid (GC) treatment, it is imperative to bring together all the necessary means for the development of novel therapies with better specificity, efficiency and limited secondary effects. To that end, it i ...
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 1

 TERMINÉ 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

 TERMINÉ 

Fighting blindness of Usher syndrome: diagnosis, pathogenesis and retinal treatment (TreatRetUsher) (TREATRUSH)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,

Usher syndrome (USH) is the most frequent hereditary cause of deafness associated to blindness. It is a rare disease, affecting 1 in every 10.000 individuals, with an autosomal recessive monogenic inheritance. Deafness is congenital while the retinitis pigmentosa is not detected before the age of 8 to 10. These patients suffer from a dreadful disability as their two major senses are impaired. Impo ...
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 13

 TERMINÉ 

REM sleep behaviour disorder: a model to investigate motor control pathway(s) and memory consolidation during REM sleep (RBD and REM SLEEP)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

REM sleep behavior disorders (RBD) are violent dream-enactments caused by loss of normal muscle atonia during REM sleep. RBD are idiopathic or associated with neurological diseases (parkinsonism, narcolepsy) and represents an exceptional window on dream content and motor control during REM sleep. The characteristics of the movements during RBD have been poorly studied. In patients with Parkinson’s ...
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 1

 TERMINÉ 

Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services (EUROGENTEST2)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe.This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the tar ...
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 22

 TERMINÉ 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

 TERMINÉ 

Understanding and combating human age-related muscle weakness (MYOAGE)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover ...
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 18

 TERMINÉ 

Restorative Plasticity At Corticostriatal Excitatory Synapses (REPLACES)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,

"Long-lasting, activity-dependent synaptic changes are thought to underlie the ability of the brain to translate experiences into memories and seem to represent the cellular model underlying learning and memory processes. Alteration of brain plasticity may lead to the motor and cognitive disturbances observed in neurodegenerative diseases. Therapeutic approaches targeting synaptic plasticity could ...
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 12

 TERMINÉ 

Rod-derived Cone Viability Factor (RDCVF)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2013,

"The discovery of RdCVF (Rod-derived Cone Viability Factor) has provided a clue to understanding the secondary loss of cone photoreceptors (and of central and light-adapted vision) following the degeneration of rod photoreceptors as a consequence of mutations expressed only in rods in most cases of rod-cone degenerations (or retinitis pigmentosa : RP). In two different rodent models of RP, intraoc ...
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 5

 TERMINÉ 

Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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 27

 TERMINÉ 

Serotonin and GABA-B receptors in anxiety : from developmental risk factors to treatment (DEVANX)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

"GABAergic and serotoninergic systems are key players in the control of anxiety states but the precise bases for their action has remained elusive. New findings, brought about by members of this consortium, are radically changing our views on the neurobiological action of these two transmitters and will be the focus of the present proposal. The first original dimension is the discovery of a develo ...
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 8

 TERMINÉ 

Detecting and Eliminating Bacteria UsinG Information Technologies (DebugIT)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2012,

Description For infectious diseases DebugIT detects patient safety related patterns and trends, acquires knowledge and uses this for better quality healthcare In about half a century of antibiotic use, unexpected new challenges have come to light: fast emer-gence of resistances among pathogens, mi ...
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 14

 TERMINÉ 

Visual Impairment and Degeneration: A Road-map for Vision Research within Europe (EuroVisionNet)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

The coordination project EuroVisionNet aims to link the research activities and policies of the European vision research community and to overcome the national fragmentation, therewith intends to become an essential “instrument” for vision research in the 21st century. To reach this goal the following 4 objectives will be addressed: (1) scientific integration of European vision research; (2) colla ...
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 10

 TERMINÉ 

Molecular mechanisms involved in the IGF-1R signalling setting of the somatotropic axis (MISS-SA)

Date du début: 1 sept. 2009, Date de fin: 31 déc. 2011,

"This proposal aims to understand molecular mechanisms involved in the induction and persistence of the somatotropic function decrease observed in mice with diminished IGF-I signalling. This alteration could be induced by a specific heterozygous IGF-1R invalidation in mice brain, and in wild type mice, by a nutrient restriction during the first two weeks of life. Previous results obtained in these ...
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 1

 TERMINÉ 

Dynamics of second messengers in axon guidance: decrypting the codes (Messenger Codes)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2011,

The mature nervous system is an intricate network in which neurons are connected to specific partners. The construction of the network requires directed growth of axons towards their appropriate targets during development and during neuronal regeneration after a lesion. Axons must navigate through a complex environment where they are guided by a combination of attractive and repulsive molecules. C ...
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 1

 TERMINÉ 

Inhibiting Nef: a novel drug target for HIV-host interactions (iNEF)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

Although HIV-1 Nef was originally named "negative factor," it has been shown to be critical for efficient persistance of HIV-1 infected humans thus playing a major role in the progression to AIDS. Remarkably; until now Nef has not been evaluated as an antiretroviral drug target. It is well established that Nef promotes HIV-1 replication and facilitates viral immune evasion by interacting with vari ...
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 9

 TERMINÉ 

"European Networks of Centres of Expertise for CF (Cystic Fibrosis), LAM (Lymphangioleiomyomatosis), and LTX (Lung Transplantation)" (ENCE-CF-LAM-LTX)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2011,

"European Centres of Expertise Networks for rare diseases have been identified by the European Commission as one important area of future activity in the attempt of achieving one of the main objectives across the EC endeavour of “Optimising the delivery of health care to European Citizens”. It is obvious that especially in rare diseases the joined forces of the experts networking throughout Europe ...
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 8

 TERMINÉ 

Implication of connexin 43 in chronic renal failure (Cx43-CRF)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2010,

Chronic renal failure (CRF), one of the main causes of disability in western societies, is promoted by a variety of factors including hypertension, diabetes, ischemic, immunological and toxic injury. These factors are linked by their common ability to promote chronic inflammation and fibrosis leading to decline of renal function. Dialysis and transplantation are the only available options that all ...
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 1