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Plus de 40 projets européens trouvés

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 TERMINÉ 

Quantitative analysis of variability and robustness in spatial pattern formation (SPACEVAR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

During embryonic development a single cell turns into a complex organism. This process is characterized by an antagonism between variation and stability. On the one hand, development is a tightly controlled process; tissues need to be specified at the right time, at the correct spatial position, and with a defined size. On the other hand, regulation should not be too rigid, since embryos need to a ...
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 1

 TERMINÉ 

Neural mechanisms of multisensory perceptual binding (ACoolTouch)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Sensory perception involves the discrimination and binding of multiple modalities of sensory input. This is especially evident in the somatosensory system where different modalities of sensory input, including thermal and mechanosensory, are combined to generate a unified percept. The neural mechanisms of multisensory binding are unknown, in part because sensory perception is typically studied wit ...
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 1

 TERMINÉ 

circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particular ...
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 8

 TERMINÉ 

Evolutionary genomics: new perspectives and novel medical applications (EvoGenMed)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

To make for better diagnostics and safer applications of genomics we need a better understanding of our genome and how it functions. Until recently we thought we knew: intergenic sequence must be largely “junk” and mutations that, for example, affect genes but not the protein (synonymous mutations) must be effectively neutral. This degenerate genome view accords with the nearly-neutral theory’s pr ...
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 3

 TERMINÉ 

DNA end protection in Immunity and Cancer (DNAendProtection)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

This proposal addresses a fundamental issue in molecular biology: how is repair of DNA double-strand breaks (DSBs) steered towards the appropriate physiological outcome? DSBs are cytotoxic DNA lesions that arise as a by-product of DNA replication, but also as a physiological intermediate during antigen receptor diversification in the Immune system. DNA end processing is a major determinant of DSB ...
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 1

 TERMINÉ 

Safeguarding Cell Identities: Mechanisms Counteracting Cell Fate Reprogramming (REPROWORM)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Regenerating tissues by reprogramming cells has the potential to become a therapeutic approach for replacing lost tissues in patients suffering from injury or degenerative diseases such as Alzheimer’s or Muscular Dystrophy. Strategies to generate required tissues using embryonic stem cells or induced pluripotent stem cells (iPSCs) are associated with either ethical or medical safety issues. An alt ...
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 1

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

 TERMINÉ 

Structural basis of mitochondrial inner membrane shape and dynamic (MitoShape)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM). The mitochondrial IM contains membrane invaginations called cristae. These are connected by tubular openings, the crista junctions, to the remaining IM. Mitochondrial shape constantly changes due to membrane fission and fusion events, and a ba ...
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 1

 TERMINÉ 

Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Date du début: 1 oct. 2015, Date de fin: 31 mars 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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 11

 TERMINÉ 

Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongl ...
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 12

 TERMINÉ 

Personalised Decision Support for Heart Valve Disease (EurValve)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2019,

Valvular Heart Disease currently affects 2.5% of the population, but is overwhelmingly a disease of the elderly and consequently on the rise. It is dominated by two conditions, Aortic Stenosis and Mitral Regurgitation, both of which are associated with significant morbidity and mortality, yet which pose a truly demanding challenge for treatment optimisation. By combining multiple complex modelling ...
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 14

 TERMINÉ 

METABOLIC BASIS OF NEURODEGENERATIVE DISEASE (BeyOND)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Alzheimer disease (AD) is the most common form of age-related dementia affecting millions of patients worldwide. Disturbingly, disorders of lipid and glucose metabolism emerge as major risk factors for onset and progression of neurodegeneration in the human population. Thus, an increasing life expectance combined with an observable rise in metabolic disturbances is expected to turn AD into one of ...
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 1

 TERMINÉ 

SMALL MOLECULES TO TREAT METABOLIC SYNDROME (PREVMETSYN)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2018,

SMALL MOLECULES TO TREAT METABOLIC SYNDROMEMetabolic Syndrome (MS) is defined as a cluster of inter-related symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension that promote the development of type 2 diabetes mellitus, cardiovascular diseases and certain cancers. In this project a pharmacological strategy will be developed that could alleviate the vicious circle o ...
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 1

 TERMINÉ 

Dissecting the mechanisms of miRNA function (miRfunction)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

miRNAs are crucial regulators of gene expression that target more than half of eukaryotic genes and play a role in human diseases, including cancer and neurological disorders. Therefore, it is important to understand the molecular mechanisms underlying miRNA-mediated repression. miRNAs act as guides recognizing their target mRNAs by partial complementarity and recruiting a complex of proteins that ...
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 1

 TERMINÉ 

Peripheral and Central Mechanisms of Temperature Detection and Core Body Thermoregulation (ThermoReg)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2018,

Internal temperature homeostasis is of critical importance to our health as deviation from a normal, tightly controlled level (37 °Celsius) can cause fatal organ failures. Temperature-sensitive cells in the hypothalamus detect deep brain temperature, which is directly relevant to core body temperature (CBT) regulation. However molecules and mechanisms underlying central temperature detection by hy ...
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 2

 TERMINÉ 

Impact of stress-induced transposon activities on human disease (TRANSPOSOstress)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The evolutionary success of transposable elements (TEs) is underscored by the finding that about 45% of the human genome is TE-derived. However, recent high throughput approach studies indicate that the impact of TE-associated activities was seriously underestimated. The first objective is to investigate the impact of TE-derived activities on the human genome in general and on disease mechanisms i ...
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 1

 TERMINÉ 

The European non-coding RNA network (RNATRAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"Non-coding RNA (ncRNA) is a new research field in rapid development. It holds the potential to explain many fundamental biological phenomena and there is a vast prospective for the development of ncRNA-derived diagnostic and therapeutic tools. Hence, biotech and pharmaceutical companies are actively looking into this unexplored territory for novel targets. Therefore, there is a substantial and un ...
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 11

 TERMINÉ 

A systems and targeted approach to alternative splicing in the developing and diseased heart: Translating basic cell biology to improved cardiac function (CARDIOSPLICE)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2017,

Cardiovascular disease keeps the top spot in mortality statistics in Europe with 2 million deaths annually and although prevention and therapy have continuously been improved, the prevalence of heart failure continues to rise. While contractile (systolic) dysfunction is readily accessible to pharmacological treatment, there is a lack of therapeutic options for reduced ventricular filling (diastoli ...
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 1

 TERMINÉ 

Enzymatic DNA deamination and the immunity/cancer balance (APOBEC)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2017,

Genomic instability is a key hallmark of cancer. Chromosome translocations require the formation of pairs of double-strand breaks (DSB) and trans-chromosomal ligation of the broken ends. Members of the AID/APOBEC family of enzymes deaminate cytosine (C) to uracil (U) in the context of a polynucleotide substrate. Excision of the U residue from DNA produces an abasic site, leading to incision of the ...
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 1

 TERMINÉ 

Molecular exploitation of an extremophile mammal (EXTREMOPHILE MAMMAL)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

"The African naked mole-rat (Heterocephalus glaber) is an unusual rodent species that has evolved physiological strategies to adapt to an extreme ecological niche. It is the only poikilothermic mammal (cold-blooded), has an extraordinarily long life span for its small size (in excess of 30 years) and lives in large colonies organized like those of termites (eusocial). We have shown that naked mole ...
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 1

 TERMINÉ 

Characterization of direct reprogramming-regulating factors LIN-53 and USP-48 (REPROL53U48)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"Cellular replacement therapies for treating degenerative diseases such as Alzheimer’s will require the generation of lost tissues by reprogramming cell types. While one strategy is to de-differentiate somatic cells into induced pluripotent stem cells with subsequent re-differentiation, an alternative strategy is to directly convert cells to the target cell type by using specific Transcription Fac ...
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 1

 TERMINÉ 

Modeling lymphoma pathogenesis in mice - from basic mechanisms to pre-clinical models (LYMPHOMA)

Date du début: 1 juil. 2011, Date de fin: 31 déc. 2016,

Human B cell lymphomas including multiple myeloma and Hodgkin¿s disease are frequent malignancies and a major clinical problem. Their high incidence is due to special features of normal B cell development that promote chromosomal translocations and other genetic alterations. Another contributing factor is Epstein-Barr-Virus (EBV), a B cell-transforming virus endemic in humans. EBV-infected cells a ...
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 1

 TERMINÉ 

Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (AMD) (TARGETAMD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Age-related Macular Degeneration (AMD), a neurodegenerative disease of the retina, is a major cause of blindness in elderly people. Due to the aging population, AMD has been referred to as a “time bomb” in society. In the exudative form of AMD, high levels of vascular endothelial cell growth factor (VEGF) and low levels of pigment-epithelial derived factor (PEDF), an inhibitor of vascularization a ...
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 16

 TERMINÉ 

Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes (TheLiRep)

Date du début: 1 mai 2015, Date de fin: 31 oct. 2016,

Diabetes is a degenerative disease that affects over 350 million persons worldwide. Type 1 and type 2 diabetes are associated with either destruction or dysfunction of pancreatic insulin-producing β cells. Despite the availability of insulin as treatment to temporarily restore the glucostasis, this remedy is unable to avoid either the acute dangers of hypoglycemia or the long-term complications of ...
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 1

 TERMINÉ 

Dynamic Signal Transduction in Individual Cells (DYNASTIIC)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Regulation of proliferation and differentiation is a fundamental challenge for multicellular organisms. The decision between alternative cell fates is therefore tightly controlled by cellular signaling. During the past decades, the central components of the signaling machinery have been identified. The challenge we are facing now is to understand how signaling networks act dynamically in living ce ...
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 2

 TERMINÉ 

Wnt/calcium signaling in cardiovascular development (WNT/CALCIUM IN HEART)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

While much is known about genetically encoded developmental pathways, the mechanisms by which the electrochemical cues interact with traditional morphogenetic pathways during embryogenesis are poorly understood. The central idea of the proposed research is to understand the interplay between major signaling pathway and electrochemical cues during embryogenesis as well as in disease. We have develo ...
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 1

 TERMINÉ 

Brain states, synapses and behaviour (BRAINSTATES)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

Global changes in patterns of neuronal activity or brain state are the first phenomenon recorded in the awake human brain (1). Changes in brain state are present in recordings of neocortical activity from mouse to man. It is now thought that changes in brain state are fundamental to normal brain function and neuronal computation. Despite their importance, we have very little idea about the under ...
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 1

 TERMINÉ 

Managing Risks of Nanoparticles (MARINA)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

While there are standard procedures for product life cycle analysis, exposure, hazard, and risk assessment for traditional chemicals, is not yet clear how these procedures need to be modified to address all the novel properties of nanomaterials. There is a need to develop specific reference methods for all the main steps in managing the potential risk of ENM. The aim of MARINA is to develop such ...
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 54

 TERMINÉ 

Molecular Mechanisms Regulating Pancreatic Islet Vascularization (ISLETVASC)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

Many reports indicate the number of people with diabetes will exceed 350 million by the year 2030. Both type 1 and type 2 diabetes are characterized by the deterioration and impaired function of pancreatic b-cells. While transplantation is a promising strategy to replace lost tissue, several obstacles remain in the pathway to its clinical application. Whether b-cells are derived from patient sampl ...
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 1

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 

Condition specific RNA Regulatory Maps (RNARegMap)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

RNA-binding proteins (RBPs) regulate the processing and expression of protein-coding transcripts. The goal of the proposed research is to develop a strategy to determine specific mRNA regulatory factors and elements important for investigating any biological processes. First, we will construct a transcriptome-wide post-transcriptional regulatory map of RBP-mRNA interactions by probabilistic modeli ...
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 1

 TERMINÉ 

European Infrastructure of Open Screening Platforms for Chemical Biology (EU-OPENSCREEN)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

The EU-OPENSCREEN Preparatory Phase forms the basis for the construction and operation of a pan-European infrastructure of open screening platforms for Chemical Biology. EU-OPENSCREEN will bring together leading laboratories from 14 European countries covering all aspects of Chemical Biology from high-throughput screening with a dedicated compound library to assay development, chemical synthesis f ...
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 24

 TERMINÉ 

European large-scale functional genomics in the rat for translational research (EURATRANS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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 19

 TERMINÉ 

Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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 19

 TERMINÉ 

MECHANISMS UNDERLYING CELL FATE DECISION BETWEEN PANCREAS AND LIVER (HEPATOPANCREATIC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,

"Diabetes is a degenerative disease affecting millions of persons worldwide. A cure for diabetes depends on replacing the insulin-producing ²-cells in the pancreas that are destroyed by the disease. An attractive strategy to attain this goal is to convert liver adult cells of the same patient into pancreatic ²-cells. The liver and pancreas share many aspects of their early development and are spec ...
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 1

 TERMINÉ 

Global characterization of post-transcriptional regulatory interactions in DNA damage response (PostScribeDNAdamage)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,

"The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput “omics” approaches.The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors. These activate the ""late"" transcriptional rep ...
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 1

 TERMINÉ 

Function of the transcription factors Olig3 and Lbx1 in brainstem respiratory nuclei (Olig3-Lbx1 breathing)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,

Congenital Central Hypoventilation Syndrome (CCHS also known as Ondine’s curse) is a lethal condition in newborn children characterized by respiratory arrest during sleep. The understanding of breathing disorders is currently limited due to our scarce knowledge of the developmental program that controls the establishment of respiratory centers in the brainstem. The solitary tract (NTS) and retrotr ...
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 1

 TERMINÉ 

European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,

"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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 19

 TERMINÉ 

Capturing kinase-substrate pairs in intact mammalian cells by using unnatural amino acid mutagenesis and photocrosslinking (Kinase crosslinking)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,

Aim of this project is to develop a method for capturing kinase-substrate pairs in living mammalian cells using unnatural amino acid mutagenesis and affinity crosslinking. Photocrosslinking amino acids (containing benzophenone or azide groups) will be introduced site-specifically into the backbone of target proteins using ad hoc developed orthogonal tRNA/synthetase pairs functional in mammalian ce ...
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 1

 TERMINÉ 

Regulation and function of the E3 ubiquitin ligases Muscle RING finger 1 and 3 in cardiac hypertrophy (MuRF and hypertrophy)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,

Heart failure caused by cardiac hypertrophy is a growing epidemic and remains the most frequent cause of hospitalization in elderly patients in the European Union. However, molecular mechanisms leading to cardiac hypertrophy and its transition into heart failure are poorly understood. Maintenance of cardiac structure and function requires a precise control of protein synthesis and degradation; abn ...
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 1