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16 projets européens trouvés

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 TERMINÉ 

Bacterial evolution of hypersensitivity and resistance against antimicrobial peptides (resistance evolution)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

Evolution of resistance towards a single drug simultaneously increases (cross-resistance) or decreases (collateral sensitivity) fitness to multiple other antimicrobial agents. The molecular mechanisms driving cross-resistance are relatively well described, but it remains largely unclear how frequently does genetic adaptation to a single drug increase the sensitivity to others and what the underlyi ...
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 1

 TERMINÉ 

Brain barriers training (BtRAIN)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of ...
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 11

 TERMINÉ 

Epigenetic regulation of endocrine therapy resistance in breast cancer: A systems medicine approach to predict treatment outcome (EpiPredict)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The mission of EpiPredict is to train a multidisciplinary cohort of young researchers in a new approach to fully exploit the epigenetics of complex diseases. The 12 early-stage researchers (ESRs) will focus on a narrowly defined case, Tamoxifen-induced resistance in Estrogen Receptor positive (ER+) breast cancer, considering five resistance interacting pathways. Given the frequent Tamoxifen treatm ...
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 8

 TERMINÉ 

Dual exploitation of natural plant strategies in agriculture and public health: enhancing nitrogen-fixation and surmounting microbial infections (SYM-BIOTICS)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2017,

"With an unprecedented increase in the human population, higher agricultural production, enhanced food safety and the protection against alarming rise of antibiotic resistant pathogenic bacteria are amongst the main challenges of this century. This proposal centered on Rhizobium-legume symbiosis aims at contributing to these tasks by i) understanding the development of symbiotic nitrogen fixing ce ...
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 1

 TERMINÉ 

Circulating Tumor Cells TheRapeutic APheresis: a novel biotechnology enabling personalized therapy for all cancer patients (CTCtrap)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

"Chemotherapy is slowly being supplemented by a new generation of drugs that recognize specific targets in or on cancer cells and has proven to be more effective with markedly fewer side effects. During the course of the disease alternative oncogenic signaling pathways take over inevitably leading to drug resistance. As a consequence renewed tumor analysis is required to redefine the optimal treat ...
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 12

 TERMINÉ 

Evolution of eukaryotic intron splicing (INTRON42)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,

Introns are non-coding intervals that interrupt the codingsequences of eukaryotic genes. Intron removal is performedby a complicated molecular machinery, called thespliceosome, concomitantly with gene transcription. Intronsand the splicing machinery (or at least their traces) arefound in every sequenced eukaryotic genome. Moreover, manyintrons are found at homologous positions across differentking ...
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 1

 TERMINÉ 

Creating the Hungarian Centre of Excellence for Molecular Medicine (HU-MOLMEDEX)

Date du début: 1 juin 2015, Date de fin: 31 mai 2016,

Existing European disparity in research and innovation performance is a barrier to competitiveness and growth. To overcome this disparity, the leading institute in molecular life sciences and three research universities of Hungary have joined forces forming a new Centre of Excellence for Molecular Medicine (HCEMM). These institutions have the necessary basic research and clinical portfolio to init ...
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 7

 TERMINÉ 

Cancer Gene Discovery Using Somatic Gene Transfer in Mice (CGDM)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

"Cancer is the leading cause of death in the developed world. Significant emphasis has recently been placed on the characterization of the human cancer genome. However, the genetic complexity of cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumours. Forward genetic screens are powerful methods to identify genes involved in specif ...
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 1

 TERMINÉ 

European Plant Phenotyping Network (EPPN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The ability to quantitatively analyze plant phenotypic traits (from single cells to plant and stand level) and their dynamic responses to the environment is an essential requirement for genetic and physiological research, and the cornerstone for enabling applications of scientific findings to bioeconomy. Whereas molecular profiling technologies allow today the generation of a large amount of data ...
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 14

 TERMINÉ 

Metabolic Flux Analysis and Cancer (METAFLUX)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

"The post-genomic era has been driven by the development of technologies that allow the function of cells and whole organisms to be explored at a molecular level. Metabolomics is concerned with the measurement of global sets of low-molecular-weight metabolites, which represent important indicators of physiological or pathological states of organisms. Such profiles provide a more comprehensive view ...
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 9

 TERMINÉ 

Control of Light Use Efficiency in Plants and Algae - From Light to Harvest (HARVEST)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"Photoprotection against excess absorbed light energy is an essential and universal attribute of oxygenic photosynthetic organisms. This requirement has been a strong force in the evolution of plants and micro-organisms, and a diverse range of solutions have arisen. It has determined survival, productivity and habitat preference, and it determines the ceiling on the efficiency of energy conversion ...
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 18

 TERMINÉ 

Integrated evolutionary analyses of genetic and drug interaction networks in yeast (network evolution)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,

The ability of cellular systems to adapt to genetic and environmental perturbations is a fundamental but poorly understood process both at the molecular and evolutionary level. There are both physiological and evolutionary reasonings why mutations often have limited impact on cellular growth. First, perturbations that hit one target often have no effect on the overall performance of a complex syst ...
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 1

 TERMINÉ 

Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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 27

 TERMINÉ 

BRAssinosteroid Venture Increasing StudentS' International MObility (BRAVISSIMO)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"A future challenge for the European agriculture is to satisfy the growing demands for food in a sustainable manner. Understanding the basic mechanics of plant growth will ultimately lead to our ability to increase yield, while decreasing the need for fertilizer and pesticides. Plant growth is regulated by developmental programmes that can be modified by environmental cues acting through endogenou ...
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 8

 TERMINÉ 

European Solar-Fuel Initiative - Renewable Hydrogen from Sun and Water. Science Linking Molecular Biomimetics and Genetics (SOLARH2)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,

"SOLAR-H2 brings together 12 world-leading European laboratories to carry out integrated, basic research aimed at achieving renewable hydrogen (H2) production from environmentally safe resources. The vision is to develop novel routes for the production of a Solar-fuel, in our case H2, from the very abundant, effectively inexhaustible resources, solar energy and water. Our multidisciplinary experti ...
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 12

 TERMINÉ 

Developmental Molecular Pathways in Drosophila as a Model for Human Cancer (CancerPathways)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,

Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution wi ...
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 8