13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
Voir le projet
38
Participants partenaires
TERMINÉ
"Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes" (EXALT)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one a ...
Voir le projet
7
Participants partenaires
TERMINÉ
Role of the transcription factor ChREBP and its associated proteins in the development and progression of NAFLD (LIPIDOLIV)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Changes in lifestyle have resulted in a dramatic epidemic of type 2 diabetes and obesity. Among associated complications, Nonalcoholic Fatty Liver Disease (NAFLD) is emerging as the most common chronic liver disease and is gaining increasing recognition as a component of the epidemic of obesity. NAFLD is generally asymptomatic, although a minority of patients may present progressive liver injury ...
Voir le projet
1
Participant partenaire
TERMINÉ
European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
Voir le projet
38
Participants partenaires
TERMINÉ
Translational research (training) in Polycystic Kidney Disease (TranCYST)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disorder with a prevalence of more than 1:1000, characterized by the development of renal cysts, slowly progressing towards end-stage renal disease. ADPKD is often associated with extra-renal complications, which can be devastating. Current therapy is directed towards limiting the morbidity and mortality from these complic ...
Voir le projet
7
Participants partenaires
TERMINÉ
"HIF and hepcidin : missing links between infection, iron metabolism and cancer ?" (HIFHEPC)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
"HIF transcription factors, central mediators of cellular adaptation to critically low oxygen levels (=hypoxia), have been largely studied for their crucial role during cancer development. Our recent findings have unveiled two new major roles of HIF. First, in innate immunity and infection, we demonstrated the key contributions of HIFs in regulating important immune effectors molecules. Second, we ...
Voir le projet
1
Participant partenaire
TERMINÉ
Post-transcriptional Control of the Aire-Driven expression of self-antigens in the Thymus (CADET)
Date du début: 1 août 2011, Date de fin: 31 juil. 2015,
Immune tolerance is key to the maintenance of the integrity of organisms against foreign invaders with respect to self-constituents. Deregulation of this mechanism promotes the occurrence of life-threatening autoimmune diseases that affect 5-10% of the general population. Previously, the transcriptional activator (Aire) was shown to play a key role in immune tolerance. Indeed, Aire induces medulla ...
Voir le projet
1
Participant partenaire
TERMINÉ
European Communication on Research Awareness Needs (ECRAN)
Date du début: 1 sept. 2012, Date de fin: 31 août 2014,
"The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with me ...
Voir le projet
10
Participants partenaires
TERMINÉ
Blood-brain barrier junctions as targets for paracellular drug delivery to the brain (JUSTBRAIN)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2014,
"To maintain homeostasis of the central nervous system (CNS) the blood-brain barrier (BBB) prevents the free transcellular passage of hydrophilic molecules from the blood into the CNS. Because of this, the BBB is now recognised as the major obstacle to the treatment of most neurological disorders, as it hinders the delivery of many potentially important therapeutic and diagnostic substances to the ...
Voir le projet
8
Participants partenaires
TERMINÉ
Epigenetic regulation of the sex chromosomes and male infertility (EPIGEFXY)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2013,
"Human infertility affects ~15% of couples, each partner being equally likely to be affected. Sperm differentiation anomalies such as sperm absence, malformation or reduced motility, are commonly found in infertile men but their cause remains unknown in ~75% of the cases. In mammals, sperm differentiation requires a high proportion of genes located on the sex chromosomes and a tight epigenetic con ...
Voir le projet
1
Participant partenaire
TERMINÉ
European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
Voir le projet
10
Participants partenaires
TERMINÉ
European clinical research infrastructures network for clinical trials and biotherapy - preparatory phase for the infrastructure (ECRIN-PPI)
Date du début: 1 mars 2008, Date de fin: 31 déc. 2011,
"European clinical research needs an integrated and distributed infrastructure able to provide efficient support to multinational clinical trials, taking advantage of the European population and competencies, unlocking latent expertise and patients scattered across the EU member states. ECRIN (European Clinical Research Infrastructures Network) is designed to bridge the fragmentation of clinical r ...
Voir le projet
22
Participants partenaires
TERMINÉ
Targeting assembly of infectious HIV particles (HIV ACE)
Date du début: 1 mars 2008, Date de fin: 31 août 2011,
"AIDS remains one of the major life threatening infectious diseases in the world today. A constant supply of novel antiretrovirals (ARVs) is needed to respond to the limitations of current drugs. By the end of 2007, the therapeutic arsenal against HIV is expected to comprise ARVs blocking all major steps of HIV replication, except for particle assembly and budding. Members of HIV-ACE were instrume ...
Voir le projet