4 projets européens trouvés
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TERMINÉ
Novel insights into cardiac regeneration through studies in the zebrafish (zebraHeart)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Myocardial infarction (MI) leads to cardiomyocyte death and accumulation of myofibroblasts (MFs) at the site of injury, which produce large amounts of extracellular matrix (ECM), generating a scar. Initially, cardiac fibrosis protects from ventricular wall rupture, but subsequent myocardial remodelling causes heart failure, representing a leading cause of death in Europe. While MFs play a central ...
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2
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TERMINÉ
Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation (GENTRIS)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
"Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS ...
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2
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TERMINÉ
Oxygen sensing in cardiovascular progenitors cell fate decisions (Hypoxia & Cell Fate)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,
Cardiogenesis is a complex process that involves different cell types that have to mature to form the final functional heart compartments. Isl1 cardiovascular progenitors label the “second heart field” and contribute to myocardial, smooth muscle and endothelial structures of the heart. These progenitors have been extensively studied but little is know about the extracellular signals mediating thei ...
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1
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TERMINÉ
Role of PPARgamma in the interstitial fluid volume regulation and contribution to cardiovascular complications of TZDs (PGFC)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,
"Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabol ...
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