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 TERMINÉ 

‘Filming’ excited state structural dynamics in photosynthesis and organic semiconductors (StructDyn)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

I wish to record ‘atomic movies’ of the structural quantum response in photoexcited chromophores.The structure of molecules relaxes as a response to photoexcitation. Coherent atomic relocations are thought to be important in photosynthesis and they ‘wire’ together distant electronic systems on conjugated polymer chains. The structural details of such atomic motions remain today elusive, because ex ...
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 1

 TERMINÉ 

Spatial protein quality control and its links to aging, proteotoxicity, and polarity (QualiAGE)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

Propagation of a species requires periodic cell renewal to avoid clonal senescence. Mylaboratory has described a new mechanism for such cell renewal in yeast, in which damagedprotein aggregates are transported out of the daughter buds along actin cables to preserveyouthfulness. Such spatial protein quality control (SQC) is a Sir2p-dependent process and by establishing the global genetic interactio ...
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 1

 TERMINÉ 

"Travels, transmissions and transformations in the 3rd and 2nd millennium BC in northern Europe: the rise of Bronze Age societies" (THE RISE)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

"Research problem: The 3rd and 2nd millennium was a period that saw major social and cultural transformations in Europe, from migrations and the introduction of metal (the Bronze Age) to new cultural identities and languages. As these two millennia were formative for Europe’s later history, these are hotly debated issues. However, they can now be resolved, at least in part, by the application of n ...
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 2

 TERMINÉ 

Regulation of gene expression in mammalian mitochondria (GENEMIT)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,

"The mitochondrial network produces the bulk part of the energy mammalian cells need through the oxidative phosphorylation process. The importance of mitochondria is underscored by the fact that deficient oxidative phosphorylation causes a wide number of genetic diseases. It is also heavily implicated in age-associated disease and ageing. Expression of mammalian mtDNA is of key importance for main ...
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 2

 TERMINÉ 

THE ENZYMATIC MACHINERY OF HUMAN MITOCHONDRIAL DNA MAINTENANCE (REPMIT)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

SUMMARYMitochondria are required to convert food into usable energy forms and every cell contains thousands of them. Unlike most other cellular compartments, mitochondria have their own genomes (mtDNA) that encode for 13 of the about 90 proteins present in the respiratory chain. All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encod ...
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 1

 TERMINÉ 

Design as driver of innovation and competitiveness (DESMA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"DESMA is a training network including 4 leading universities, 4 design consultancies and 4 product and service organizations in the area of Design Management - an area of research and practice that is concerned with the dynamic intersection of design and management. The great potential of design as a driver of innovation and competitiveness is increasingly celebrated in the popular and scholarly ...
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 13

 TERMINÉ 

Ultrasmall Chemical Imaging of Cells and Vesicular Release (NANOCELLIMAGE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

The long-term goal of this research is to establish the chain of molecular events associated with (1) neurotransmitter release at the single cell and subcellular level and (2) with cell differentiation and reprogramming. These are incredibly important goals for which there are few analytical chemistry methods that are available and useful. The immediate goal therefore includes development of three ...
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 2

 TERMINÉ 

Global Mercury Observation System (GMOS)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

The overall goal of the proposed project is to develop a coordinated global observation system for mercury able to provide temporal and spatial distributions of mercury concentrations in ambient air and precipitation over land and over surface waters at different altitudes and latitudes around the world. This will then provide high quality data for the validation and application of regional and g ...
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 25

 TERMINÉ 

Data without Boundaries (DWB)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2015,

While access to anonymised official microdata for researchers is still uneven both at national and at European level, access to highly detailed and sensitive microdata is now increasingly on the agenda. Different member states have substantially different outcomes for research access to Official data, and the issue is not just efficiency, but real harm to the contribution of the social sciences to ...
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 29

 TERMINÉ 

Formalization of Constructive Mathematics (MATHFOR)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

The general theme is to explore the connections between reasoning and computations in mathematics. There are two main research directions. The first research direction is a refomulation of Hilbert's program, using ideas from formal, or pointfree topology. We have shown, with multiple examples, that this allows a partial realization of this program in commutative algebra, and a new way to formulate ...
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 1

 TERMINÉ 

Association of European Marine Biological Laboratories (ASSEMBLE)

Date du début: 1 mars 2009, Date de fin: 31 oct. 2014,

Europe has a very long and distinguished history in Marine Biology and its coastal marine biological stations are the oldest in the world. For example, Stazione Zoologica in Naples (SZN), Station Biologique in Roscoff (SBR) and Kristineberg Marine Research Station in Fiskebäckskil (KMRS) were all established in the late 19th Century. They began an enviable tradition as marine biological research s ...
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 8

 TERMINÉ 

Education as Welfare - Enhancing opportunities for socially vulnerable youth in Europe (EDUWEL)

Date du début: 1 janv. 2010, Date de fin: 31 août 2014,

The ITN 'Education as Welfare - Enhancing opportunities for socially vulnerable youth in Europe' aims to consolidate research on education and welfare and evaluate its capacity to tackle the multiple challenges and pressures a large proportion of young people in Europe faces. In examining the welfare dimensions of educational settings and the educational dimensions of welfare services, it integrat ...
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 11

 TERMINÉ 

NMR for Structural Biology (Bio-NMR)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dyna ...
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 20

 TERMINÉ 

Innovative Synthesis in Continuous-Flow Processes for Sustainable Chemical Production (SYNFLOW)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with eng ...
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 23

 TERMINÉ 

Alignment of Liquid Crystals on Patterned Surfaces (ALIPS)

Date du début: 1 juin 2010, Date de fin: 31 mai 2014,

"Patterned topographies for their potential use as alignment layers for liquid crystals are proposed. Systematically designed nano- and micro surface patterns, as a valuable tool for studying not well-understood liquid crystal/surface interactions and their effective control, will be produced by unconventional patterning techniques. A comprehensive study of the alignment and electro-optical behavi ...
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 1

 TERMINÉ 

Opti-Alert: Enhancing the efficiency of alerting systems through personalized, culturally sensitive multi-channel communication (Opti-Alert)

Date du début: 1 janv. 2011, Date de fin: 30 avr. 2014,

The objective of this project proposal is to develop an alerting tool that(a) allows for a rapid simulation of the impact of different alerting strategies (depending on the selected media-mix and current availability of communication media), (b) supports the composition of the optimal mix of communication channels (individualized alerting channels and mass media), (c) improves alert compliance thr ...
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 12

 TERMINÉ 

Nanoparticle Fate Assessment and Toxicity in the Environment (NanoFATE)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

Concept: NanoFATE has been conceived to fill knowledge and methodological gaps currently impeding sound assessment of environmental risks posed by engineered nanoparticles (ENPs). Our vision is to assess environmental fate and risk of ENPs from high-volume products for which recycling is not an option; namely; fuel additive, personal care and antibacterial products. Two market ENPs from each produ ...
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 14

 TERMINÉ 

LABORATORY ASTROCHEMICAL SURFACE SCIENCE IN EUROPE (LASSIE)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,

Astronomical observations are revealing in ever increasing detail how our Universe works. Existing and planned European investment in sophisticated observational platforms approaches many billions of Euros. However, the observations that can be made on these telescopes would be little more than "pretty pictures" were it not for the efforts of the experimental and theoretical laboratory astrophysic ...
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 13

 TERMINÉ 

EMBRC preparatory phase (EMBRC)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,

The Preparatory Phase for a pan-European MARINE BIOLOGICAL RESOURCE CENTRE(EMBRC) research Infrastructure. This application focuses on the technical, legal, governance, and financial issues to prepare a memorandum of understanding to begin to construct EMBRC. It will build on existing Marine Biological Institutes and Research Centres which will be complemented with innovative components and pro ...
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 12

 TERMINÉ 

Occurrence, distribution and cost of antibiotic resistance in marine sediment bacteria (mARibact)

Date du début: 1 avr. 2010, Date de fin: 31 déc. 2013,

The presence of antibiotic/antimicrobial substances in the marine environment is of high concern since it potentially accelerates widespread bacterial antibiotic resistance (AR), and may have negative effects on non-pathogenic bacteria responsible for sustaining vital ecosystem functions. Our understanding of how antibiotics affect, and how AR develops and spreads in natural systems is very limite ...
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 1

 TERMINÉ 

SOLUTIONS for ENVIRONMENTAL CONTRASTS in COASTAL AREAS (SECOA)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

"Urban settlements, following the economic crisis of the 70s, entered in a process of regional and urban restructuring to gain a new image at the international level. As a result of the renewed economic success new flows of permanent, semi-permanent, temporary and daily “human mobility” followed: (i) for consumption (leisure and tourism), (ii) for production (economic migration). The world competi ...
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 11

 TERMINÉ 

Monitoring Developments for safe Repository operation and staged closure (MODERN)

Date du début: 1 mai 2009, Date de fin: 31 oct. 2013,

The MoDeRn project aims at providing a reference framework for the development and possible implementation of monitoring activities and associated stakeholder engagement during relevant phases of the radioactive waste disposal process, i.e. during site characterisation, construction, operation and staged closure, as well as a post-closure institutional control phase. Monitoring provides operators ...
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 18

 TERMINÉ 

Novel multifunctional cyclodextrin-based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks (CYCLON)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"There is a high demand for the development of new drug delivery strategies to combat major diseases in our society, particularly cancer. Current treatments are based on high efficacy drugs, however their non-selective uptake by both normal and tumor cells as well as the development of multidrug resistance (MDR), constitute major hurdles. Resistance is also associated with the use of nucleoside an ...
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 9

 TERMINÉ 

Innovative Techniques and Models to Study Glia-Neuron Interactions (EdU-GLIA)

Date du début: 15 sept. 2009, Date de fin: 14 sept. 2013,

It became evident over the last 20 years that glial cells are involved in virtually every aspect of nervous system function. Neurons and glia exchange chemical signals that are essential for the normal function of the nervous system, and are crucial in disease. Recently it was discovered that glial cells also act as neural stem cells both in early development and adulthood, and in synapse formatio ...
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 14

 TERMINÉ 

Musical Interaction Relying On Reflexion (MIROR)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

Description MIROR develops an innovative adaptive system for music learning and teaching based on the reflexive interaction paradigm in the context of early childhood music education.The MIROR project deals with the development of an innovative adaptive system for music learning and teaching based on the reflexive interaction paradigm. Th ...
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 8

 TERMINÉ 

Integration of European marine research networks of excellence - Euromarine (EuroMarine)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2013,

EuroMarine is a coordination action that seeks to develop and implement an agreed framework for the long-lasting and durable co-operation between research institutions that were partners in FP6 marine Networks of Excellence in order to achieve further integration of marine research in Europe. Particular areas for cooperation will be: research programming, joint development and use of data bases, t ...
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 17

 TERMINÉ 

Formalisation of Mathematics (FORMATH)

Date du début: 1 mars 2010, Date de fin: 31 juil. 2013,

We propose to developed libraries of formalized mathematics concerning linear algebra, real number computation, and algebraic topology. The main originality of this work will be to structure these libraries as a software development, relying on a basis that has already shown its power in the formal proof of the four color theorem, and to address topics that were mostly left untouched by previous r ...
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 4

 TERMINÉ 

The zebrafish as a new vertebrate model for molecular and cellular mechanisms of learning and memory, including synaptic dysfunction in Alzheimer's disease (LEARNING AND MEMORY)

Date du début: 1 août 2011, Date de fin: 31 juil. 2013,

A majority of our most common neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, age-related dementia and multiple sclerosis, are manifested by memory loss and a reduced potential for learning. Additionally, a substantial portion of our population suffers from various forms of learning difficulties. Despite all the efforts to solve the mystery of learning and memory, we still ...
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 1

 TERMINÉ 

Marine Genomics for Users (MG4U)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2013,

"Marine waters provide resources and services estimated at 60% of the total economic value of the biosphere. The application of cutting-edge genomic approaches has generated significant new understanding the marine environment. Rapid progress will continue given the fast rate of technological development in this field. Methods and information are sufficiently mature for direct application to achie ...
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 7

 TERMINÉ 

CAAX Protein Processing in Human DIsease: From Cancer to Progeria (CAAXPROCESSINGHUMDIS)

Date du début: 1 juin 2008, Date de fin: 31 mai 2013,

"My objective is to understand the physiologic and medical importance of the posttranslational processing of CAAX proteins (e.g., K-RAS and prelamin A) and to define the suitability of the CAAX protein processing enzymes as therapeutic targets for the treatment of cancer and progeria. CAAX proteins undergo three posttranslational processing steps at a carboxyl-terminal CAAX motif. These processing ...
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 1

 TERMINÉ 

International sensor development network (SENSEnet)

Date du début: 1 juin 2009, Date de fin: 31 mai 2013,

This ITN project will train young investigators to enable them make significant advances in the field of in situ sensor technology. It will bring together 15 research groups and 2 industrial partners from across the European Union. The ITN will provide training for 16 PhD students, early stage researchers (ESRs) and 1 Postdoctoral student, experienced researcher (ER). The programme will combine th ...
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 11

 TERMINÉ 

Forging Identities: The Mobility of Culture in Bronze Age Europe (FORGING IDENTITIES)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

This ITN will continue and enhance the success of a recent RTN ‘The Emergence of European Communities (2-2001-00366)’: Several PhDs have been educated and new knowledge has been unearthed concerning the economic and political foundations of intercultural interaction in Bronze Age Europe – a golden epoch between 3000 and 500 BC with new patterns of social identification, specialised production, co ...
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 7

 TERMINÉ 

REvolutionary Approaches and Devices for Nucleic Acid Analysis (READNA)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

"The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible w ...
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 20

 TERMINÉ 

Making Capabilities Work (WorkAble)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2012,

“Making Capabilities Work” (WorkAble) will scrutinise strategies to enhance the social sustainability and economic competitiveness of Europe by strengthening the capabilities of young people to actively shape their personal and work lives in knowledge societies and cope with today's economic, cultural, demographic and technological challenges. Bridging quantitative and qualitative methods ...
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 13

 TERMINÉ 

Hotspot Ecosystem Research and Man's Impact on European seas (HERMIONE)

Date du début: 1 avr. 2009, Date de fin: 30 sept. 2012,

The HERMIONE project is designed to make a major advance in our knowledge of the functioning of deep-sea ecosystems and their contribution to the production of goods and services. This will be achieved through a highly interdisciplinary approach (including biologists, ecologists, microbiologists, biogeochemists, sedimentologists, physical oceanographers, modelers and socio-economists) that will in ...
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 41

 TERMINÉ 

Surface Electrochemical Reactivity in Electrocatalysis: A combined Theoretical and Experimental Approach (ELCAT)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"The aim of ELCAT is to train a new generation of young researchers in experimental and theoretical research methods in electrocatalysis. The scientific objectives are to address the problem of achieving specific reactivity in electrochemical transformations and to establish predictive tools based on quantum chemical calculations and computational modelling. The electrocatalytic properties of nano ...
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 9

 TERMINÉ 

Exploring the glycosylation process during infection (Infection glycomics)

Date du début: 21 janv. 2008, Date de fin: 9 mai 2012,

Cellular Glycosylation is a finely tuned process that is very suscpetible in changes due to environmental stimuli. We have preliminary data showing that intestinal infections in mice and rats are capable in changing the glycosylation profile of intestinal glycoproteins. We speculate that this could be due to a translational regulation of glycosyltransferases. Hence, we would like to use RT-PCR and ...
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 2

 TERMINÉ 

Carnivorous zooplankton – their role in Swedish marine food webs (Carnivorous Zoo)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2012,

This project will focus on how carnivorous zooplankton function in the pelagic food web and their role in structuring the pelagic community. The major objective is to determine whether there is a consistent indication of predatory control of copepods in Swedish waters. Copepods are the main food source for numerous species of fish in most marine environments. The understanding of their mortality i ...
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 1

 TERMINÉ 

Enhanced Durability Resurfacing Endoprosthesis (EnDuRE)

Date du début: 1 oct. 2009, Date de fin: 31 déc. 2011,

Each year in Europe there are:- • 800000 hip operations costing approximately €1,942 per/implant, worth over €1.5 billion • Hip implant operations are rising by approximately 15%. • Currently 10% of all the prosthesis implanted are in patients under 55 years of age of which 33% of these will fail within 16 years with a further 20% of implant fitted to over 55’s failing with in 20 years requiring r ...
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 11

 TERMINÉ 

Characterization of Reactive Oxygen Species as Innate Immune System Mediators that Control Inflammation (ROS in Inflammation)

Date du début: 1 janv. 2009, Date de fin: 31 août 2011,

Biomedical research in the post genomic era will depend on the establishment of collaborative efforts between clinical and preclinical researchers, combining bedside medical research with experimental science. This project stems from initial gene expression studies on immune compromised patients with severe inflammatory disorders. The results allowed us to generate the hypothesis that reactive oxy ...
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 1