4 projets européens trouvés
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TERMINÉ
Role of the PI3Kbeta isoform in signalling and cancer invasion (PIKbeta/cancer)
Date du début: 1 avr. 2011, Date de fin: 28 sept. 2013,
PI 3-kinases (PI3Ks) generate lipids in cell membranes which bind a variety of intracellular protein effectors, affecting their localization and/or activity. The PI3K signalling axis is one of the most frequently deregulated pathways in cancer. Mammals have 8 isoforms of PI3K, divided into three classes. The class I PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, p110delta and p110 ...
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TERMINÉ
Roles of Class I PI 3-kinase isoforms in signalling and cancer (PI3K/signal-cancer)
Date du début: 1 oct. 2010, Date de fin: 9 mars 2013,
PI 3-kinases (PI3Ks) generate intracellular lipid second messengers that regulate many cellular processes including cell survival, proliferation, migration and differentiation. The PI3K signalling pathway has been implicated in diseases such as cancer, inflammation and diabetes, and PI3Ks are therefore considered as attractive new therapeutic targets in the pharmaceutical and biotech industry. Mam ...
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TERMINÉ
In-depth quantification and characterisation of PI 3-kinase signalling networks at a System Biology level (PI3K Systems Biology)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2012,
The group of genes termed phosphoinositide 3-kinase (PI3K for short) have roles in many important biological functions and are also implicated in diseases such as diabetes, inflammation, allergy and cancer. Therefore, there are many pharmaceutical and biotechnological companies interested in targeting this pathway. There are 8 different PI3K genes and it is becoming clear that they have different ...
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TERMINÉ
Characterization of signalling and physiologic roles of the class II PI 3-kinases (PI3KC2)
Date du début: 1 août 2010, Date de fin: 31 juil. 2012,
"Phosphoinositide 3-kinases (PI3Ks) are a conserved family of lipid kinases that generate lipid second messengers inside cells. Mammals have 8 isoforms of PI3K, divided in three classes (I, II and III). The focus of research has thus far almost exclusively been on class I PI3Ks, which have been implicated in cancer, inflammation and diabetes and which are the target of ongoing drug development eff ...
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