6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Molecular signatures and Modulation of immunity to Adeno-Associated Virus vectors (MoMAAV)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
Experience with adeno-associated virus (AAV) vector-mediated gene transfer in human trials has unveiled the therapeutic potential of this approach, with some of the most exciting results coming from clinical studies of gene transfer for hemophilia B, congenital blindness, and the recent market approval of the first AAV-based gene therapy in Europe. Follow-up data of subjects treated with AAV vecto ...
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1
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TERMINÉ
Sequence similarity networks: a promising complement to the phylogenetic framework to study evolutionary biology (EVOLUNET)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
"The comparison of molecular sequences from organisms, environmental samples and mobile genetic elements is fundamental in evolutionary biology to study genes, genomes and species evolution. Although phylogenetic methods play a major role in these analyses, through the inference of phylogenetic trees or networks based on families of homologous sequences, many data remained underexplored as the num ...
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1
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TERMINÉ
Role of hevin in the neuroplasticity of stress-related disorders and addiction (matrixresilience)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Matricellular proteins mediate interaction between cells and the extracellular matrix and are essential regulators of synaptic function and architecture. Recently, the two prototypical matricellular proteins SPARC and hevin have been implicated in depression-like behaviors, antidepressant response and resilience to stress. I found that hevin is induced by chronic social stress in the nucleus accum ...
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1
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TERMINÉ
The Human Brain Project (HBP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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116
Participants partenaires
TERMINÉ
Cutaneous and Mucosal HIV Vaccination (CUT'HIVAC)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,
Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cel ...
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18
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TERMINÉ
Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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