6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Metagenomics in Cardiometabolic Diseases (METACARDIS)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,
METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
Voir le projet
18
Participants partenaires
TERMINÉ
Environmentally-induced Developmental Origins of Health and Disease (E-DOHAD)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later. Alterations of epigenetic marks, impacting on gene expression, are one mechanism that could explain such long-term impact. These hypotheses have so far been tested mostly in animals, and ...
Voir le projet
2
Participants partenaires
TERMINÉ
Bacterial Cell Morphogenesis (BaCeMo)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
In bacteria, the though external cell wall and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. The biosynthetic pathways and chemical composition of the cell wall, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex cell wall ul ...
Voir le projet
1
Participant partenaire
TERMINÉ
Simulation of the Kinetics and Inverse Problem for the Protein PolymERization in Amyloid Diseases (Prion, Alzheimer’s) (SKIPPERAD)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,
Amyloid diseases are of increasing concern in our aging society. These diseases all involve the aggregation of misfolded proteins, called amyloid, which are specific for each disease (PrP for Prion, Abeta for Alzheimer's). When misfolded these proteins propagate the abnormal configuration and aggregate to others, forming very long polymers also called fibrils. Elucidating the intrinsic mechanisms ...
Voir le projet
2
Participants partenaires
TERMINÉ
Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
Voir le projet
46
Participants partenaires
TERMINÉ
Control of Streptococcus agalactiae virulence genes via peptide-based cell to cell communication (CELLCOM-GBS)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
"Quorum sensing (QS) is a bacterial cell-to-cell communication process to control gene expression at population level. Recently, a new QS mechanism was described in streptococci. It involves a transcriptional regulator of the Rgg family and a small hydrophobic peptide (SHP), acting as a signaling molecule. The interaction between SHP and Rgg allows Rgg to control the expression of its target genes ...
Voir le projet