3 projets européens trouvés
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TERMINÉ
Exploring the role of mitochondrial dynamics in tumor regulation by Cop1 (Cop1-Drp1)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,
The Constitutive morphogenetic protein 1 (Cop1) is an E3-ubiquitin ligase regulating stability of a broad group of targets with pleiotropic functions. Cop1 emerged as a tumour suppressor in T-cell lymphomas and in prostate cancer. During tumour formation, mitochondria are key organelles regulating cell death and proliferation. This multiplicity of functions is mirrored by the complex morphology of ...
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TERMINÉ
Regulation of mitochondria-endoplasmic reticulum tethering by Parkin: implication for Parkinson’s disease (Mitofusin-PD)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,
Parkin, an E3 ubiquitin ligase and a Parkinsons's disease related gene, translocates to impaired mitochondria upon mitochondria intoxication and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusin (Mfn) was found to be a target for Parkin mediated ubiquitination. In absence of Parkin, Mfn fails to be ubiquitinated, thus accumulates in th ...
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TERMINÉ
Role of mitochondria-shaping proteins in T cell development and migration in vivo (Dyna-Mito in Thymus)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,
Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2+ signaling, to morphogenesis of dendri ...
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