Rechercher des projets européens

11 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
Voir le projet

 28

 TERMINÉ 

New approaches for the targeted therapy of Non-Small Cell Lung Cancer (LUNGTARGET)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,

Lung cancer is the most common cancer fatality in Europe (335000 deaths/yr). Non-small cell lung cancer (NSCLC) consists 85% of the cases, with 5 yr survival
Voir le projet

 10

 TERMINÉ 

Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics (PREDICT)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

"The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of t ...
Voir le projet

 16

 TERMINÉ 

CHARACTERISATION OF ARKADIA FUNCTION IN THE REGULATION OF SNON STABILITY AND ITS ROLE AS A POTENTIAL TUMOUR SUPPRESSOR (ARKADIA AND CANCER)

Date du début: 1 mars 2010, Date de fin: 29 févr. 2012,

"Deregulated signalling by transforming growth factor beta (TGF-beta) plays a critical role in tumorigenesis in humans, acting as a tumour suppressor at early stages, but as a tumour promoter at late stages. To be able to diagnose and treat human cancer, it is essential that we understand these processes at the molecular level. Recent work in the host lab has established that the E3 ubiquitin liga ...
Voir le projet

 1

 TERMINÉ 

A novel mode of TGF-beta signalling through Smad1/Smad5 phosphorylation: mechanism and functional role in cancer (Smad1/5 and cancer)

Date du début: 27 mai 2009, Date de fin: 26 mai 2011,

Ligands of the Transfroming Growth Factor-beta (TGF-beta) superfamily control numerous cellular processes such as proliferation, apoptosis, differentiation, adhesion and mobility. As a result, it is well established that they play an essential role in cancer. TGF-beta signalling has been implicated in both tumour suppression and progression. TGF-beta signals predominantly through receptor-regulate ...
Voir le projet

 1

 TERMINÉ 

In vivo study of primary B cell responses (PBC-Bs)

Date du début: 15 janv. 2009, Date de fin: 14 janv. 2011,

B cells produce antigen-specific antibodies as part of the adaptive immune response. This is the result of a complex process of activation and differentiation that is initiated with the specific engagement of the Ag to the BCR. While a wide range of studies have been performed in vitro to understand B cell-Ag recognition, we still understand very little about the basics of motility, compartimental ...
Voir le projet

 1

 TERMINÉ 

cooperation between BCL6 and c-Jun in lymphoma development and progression (BCL6-c-Jun-CAX)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2010,

Sequential activation of different oncogenes drive the step-wise progression of precancerous cells to highly malignant tumors. A molecular understanding of the transformation events is crucial to develop anti-cancer therapies. In this sense, The AP-1 transcription factor has gained special attention in the last decades due to its key role in the tumor development. AP-1 comprises a family of dimeri ...
Voir le projet

 1

 TERMINÉ 

Analysis of the molecular mechanisms of antigen presentation to B cells by macrophages in lymphoid organs (MAC-Bs)

Date du début: 1 janv. 2010, Date de fin: 30 nov. 2010,

B cell activation is triggered by antigen recognition through the B cell receptor (BCR). It has been evidently shown that the antigen encountered in vivo by B cells is mainly membrane-bound. However, the molecular events involved in the process of recognition are not yet undertaken. Dr. Batista’s lab has very recently shown that macrophages collect and concentrate particulate antigen at the lymph ...
Voir le projet

 1

 TERMINÉ 

Regulating TGF-beta signalling at the transcriptional level and in cancer (TGF-beta and Cancer)

Date du début: 11 juin 2008, Date de fin: 10 juin 2010,

To understand, treat, cure and ultimately prevent cancer we must first be able to understand the basic mechanisms that regulate normal cell growth. One of the cellular factors involved both in normal development and in malignant transformation is transforming growth factor b TGFb. TGFb is a multifunctional cytokine which, in addition to cancer is also implicated in developmental disorders, fibrosi ...
Voir le projet

 1

 TERMINÉ 

Cell Biology of SRF cofactors (SRF cofactors)

Date du début: 1 juin 2008, Date de fin: 31 mai 2010,

Serum response factor (SRF) regulates the expression of immediate-early genes as well as the expression of many muscle-specific genes. Differential regulation of the expression is achieved by exclusive binding of specific coactivators. MAL and MKL2, two coactivators of the myocardin family link SRF activity to a Rho-actin signalling pathway. Their activity is controlled through regulated interacti ...
Voir le projet

 1

 TERMINÉ 

Molecular mechanism of separase dependent PP2ACdc55 downregulation (Chromosome Stability)

Date du début: 1 juin 2008, Date de fin: 31 mai 2010,

Activation of the protease separase at anaphase onset leads to cleavage of cohesin, thereby triggering chromosome segragation. At the same time, an essential protease-independent function of separase promotes cell cycle progression out of mitosis. In the host laboratory it has been recently shown that separase interacts with the Cdc55 isoform of protein phosphatase 2A (PP2ACdc55) at anaphase onset ...
Voir le projet

 1