6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Translating neuroimaging findings from research into clinical practice (PSYSCAN)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,
Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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24
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TERMINÉ
Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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18
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TERMINÉ
p73 dependence in cancer: from molecular mechanisms to therapeutic targeting (P73CANCER)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2016,
"p73 is a transcription factor of the p53 tumor suppressor family. In approximately 50% of all cancer patientsthe tumor suppressor function of p53 is irreversibly disabled by point mutations, which makes p53 one of themost frequently mutated genes in cancer. This is entirely different for p73 and much of my previous work inthis field has been devoted to research on the role of p73 in cancer.In sha ...
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1
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TERMINÉ
Chemogenomic profiling of drug-protein binding by shape, enthalpy/entropy and interaction kinetics (DrugProfilBind)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
Once a new drug target is discovered, screening techniques are applied to detect prospective hits. However, which hit should be taken to the next level of development? This decision is most crucial as it entails huge financial commitments of the subsequent drug optimization. In consequence drugs are only developed against diseases that promise short-term profit. Chemogenomic profiling allows to co ...
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1
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TERMINÉ
microRNA function in homeostatic plasticity in the mammalian brain (NEUROMIR)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2015,
Neural circuits are constantly modified in response to experience and changes in the environment, a phenomenon known as plasticity. While classical Hebbian plasticity is crucial to encode information, a different set of mechanisms, commonly referred to as homeostatic plasticity, are used by neurons to stabilize their activity in the face of perturbations that alter excitability. Homeostatic plasti ...
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1
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TERMINÉ
Quantitative modeling of historical-comparative linguistics: Unraveling the phylogeny of native South American languages (QUANTHISTLING)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
This project aims to uncover and clarify phylogenetic relationships between native South American languages. Very little is known about the historical development of the linguistic diversity in this part of the world, and more detailed insights will have a major impact not only on linguistics, but also on genetics, archeology, and cultural anthropology. The approach taken is to digitize available ...
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