3 projets européens trouvés
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TERMINÉ
Mechanisms of chromosome segregation in mammalian oocytes (CHROMOOCYTE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
All animal life starts with the fertilization of an egg. A haploid egg and a haploid sperm fuse and together they form a new genetically unique embryo. But surprisingly, eggs frequently contain an incorrect number of chromosomes. Depending on the age of the woman, 10-50% of eggs are chromosomally abnormal. This high percentage of abnormal eggs results from chromosome segregation errors during oocy ...
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2
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TERMINÉ
Receptors, Channels and Transporters: Development and Application of Novel Technologies for Structure Determination (EMPSI)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
...poorly in these systems or may be expressed in a misfolded non-functional form. A second issue with the future structure determination of GPCRs is the lack of generic technologies to allow the crystallisation of arrestin-GPCR and G protein-GPCR complexes. Although one G protein GPCR complex has been crystallised this was exceedingly diffciult and resulted in poor resolution of the GPCR component o ...
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1
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TERMINÉ
Regulation of cell division by alternative splicing (Splicing in Mitosis)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,
The complexity of the mammalian proteome is far more extensive than can be explained by a simple one gene: one protein paradigm. The use of alternative splicing (AS) is emerging as a core regulatory mechanism, in a similar way to whether a specific gene is transcribed or repressed, or a protein is degraded or stabilised. Also like both transcriptional and post-translational control, it seems that ...
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