14 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Identification and targeting of metabolic pathways in dendritic cells that regulate their immune polarizing function (dendritic cells)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,
Dendritic cells (DCs) are key regulators of both immunity and tolerance by controlling activation and polarization of effector T helper cells (Th) and regulatory T cell responses (Treg). Therefore, there is a major focus on developing approaches to manipulate DC function for immunotherapy. It is well known that changes in cellular activation are coupled to changes in cellular metabolism. However, ...
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1
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TERMINÉ
Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)
Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,
Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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17
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TERMINÉ
Mechanisms and Treatment of Migraine and its Chronification (EUROHEADPAIN)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,
Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailmen ...
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14
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TERMINÉ
Underneath the attack: cortical network function in migraine (Underneath migraine)
Date du début: 1 sept. 2011, Date de fin: 31 août 2015,
Migraine is a disabling brain disorder with major consequences to patients and society. Diverse genetic and physiological factors predispose for attacks, stressing the need for a multidisciplinary approach. In the host team at the LUMC, the Netherlands, migraine research led to identification of the first migraine genes and generation of transgenic mice harboring mutations that cause hemiplegic mi ...
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1
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TERMINÉ
Proteomic segmentation of intratumour heterogeneity for identifying clinically relevant tumour subpopulations in gastrointestinal cancers (SITH)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2015,
"An important factor that influences therapy response and prognosis of cancer patients has been identified as intratumoral heterogeneity. Gastrointestinal cancers are known to be morphologically and molecularly very heterogeneous diseases. Thus, there is a strong need to identify clinically relevant tumor subpopulations and characterize their genetic and proteomic features. A novel technology whic ...
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1
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TERMINÉ
Explicitly Normalized ImaGing MAss Spectrometry (ENIGMAS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2014,
"Imaging Mass Spectrometry is a rapidly developing technique that uses spatially resolved proteomic techniques to investigate a tissue’s biomolecular content. Imaging MS of pharmaceuticals has demonstrated that relative quantitation can be obtained if the MS response factors are known. However MS response factors for peptides and proteins are highly dependent on their exact nature. Despite it bein ...
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1
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TERMINÉ
The targeted development of a new generation Vaccine for Schistosomiasis (TheSchistoVac)
Date du début: 1 févr. 2010, Date de fin: 31 juil. 2014,
The aim of this project is to develop a new generation vaccine for schistosomiasis. The vaccine will be based on exposed proteins and/or glycans of the vulnerable skin stage schistosomula, making it safe and effective. The life stage-specific vaccine target selection strategy is based on state-of-the-art schistosomal transcriptomics and glycomics technologies and data, and unique serum and sample ...
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14
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TERMINÉ
"Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity" (NIMBL)
Date du début: 1 juin 2010, Date de fin: 30 nov. 2013,
"Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL condition ...
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10
Participants partenaires
TERMINÉ
Genotype-To-Phenotype Databases: A Holistic Solution (GEN2PHEN)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,
"The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seaml ...
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23
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TERMINÉ
European Network for Genetic and Genomic Epidemiology (ENGAGE)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,
"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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26
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TERMINÉ
Ultra-high resolution and ultra-sensitive fluorescence methods for objective sub-cellular diagnosis of early disease and disease progression in breast and prostate cancer (FLUODIAMON)
Date du début: 1 juin 2008, Date de fin: 31 mai 2012,
"The overall objective of this proposal is to develop and validate a quantitative, minimally invasive diagnostic tool for early and conclusive detection, diagnosis and monitoring of disease and disease progression of breast and prostate cancer. A methodology will be developed making use of a combination of the probably most exciting recent advances in the field of light microscopy, for fluorescenc ...
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12
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TERMINÉ
Structural analysis of the CSA binding interactions involved during pregnancy associated malaria (PreMalStruct)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2011,
Adhesion of Plasmodium falciparum-infected erythrocytes (PE) to placental chondroitin-4-sulfate (CSA) has been linked to the severe disease outcome of pregnancy-associated malaria (PAM). After multiple pregnancies, women acquire protective antibodies that block CSA-binding and cross-react with geographically diverse placental isolates suggesting that surface molecule(s) expressed by PAM-infected e ...
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7
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TERMINÉ
A European Platform of Integrated Information Services for Researchers in the Field of Rare Diseases and Orphan Drugs Supporting Team and Project Building (RareDiseasePlatform)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,
This project aims at creating a set of tools intended to facilitate collaborations between academic teams, SMEs and even major companies, in the field of rare diseases (RD). These tools will contribute to building up a community of stakeholders with the ultimate goal of speeding up RD research and development, providing diagnostic tools and therapies as quickly as possible. The specific objectives ...
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13
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TERMINÉ
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)
Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,
The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal fra ...
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