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15 projets européens trouvés

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 TERMINÉ 

Neural and Immune Orchestrators of Forebrain Wiring (NImO)

Date du début: 1 sept. 2014, Date de fin: 31 août 2019,

Forebrain functioning relies on complex circuits that begin to be established in the embryo by intrinsic developmental programs. Such programs coordinate the assembly of millions of neurons via an integrated choreography of neuronal migration and axonal navigation, which remains largely to be explored. In addition, intrinsic programs can be modulated by maternal environment, as illustrated by the ...
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 1

 TERMINÉ 

Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples (MyeloSHOCK)

Date du début: 1 sept. 2014, Date de fin: 31 août 2019,

Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific IgE and that release histamine when encountering allergen. Clinical cases, however, report anaphylaxis in the absence of specific IgE or medical history of allergy. We ...
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 1

 TERMINÉ 

HOMEOSIGN : Homeoprotein signaling during development and in the adult (HOMEOSIGN)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

"Homeoprotein (HP) signaling designates the ability of HP transcription factors to transfer between cells, thus acting as signaling molecules. We will investigate several properties of this novel signaling pathway in the CNS and how it can shed light on brain development and physiology, also neurological and psychiatric pathologies. The studies will concentrate on 4 HPs (Engrailed1/2, Otx2 and Pax ...
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 1

 TERMINÉ 

Blood vessels as a target for infection (VIP)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

One of the major challenges in bacterial infectious disease relates to infections taking place in the bloodstream (septicemia). Despite availability of antibiotics these types of infections lead to extremely severe conditions such as septic shock or meningitis requiring a better understanding of mechanisms of disease. The common denominator of these conditions is the interaction of pathogens with ...
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 1

 TERMINÉ 

Molecular Plasticity of Inhibitory Synapses (PLASTINHIB)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"Neurons maintain a precise organization of their membrane into sub-domains with specific molecular compositions, together with the capacity to change it in response to plasticity events. However, as seen with the tracking of single molecules, receptors in the plasma membrane continuously exchange between synaptic and extrasynaptic locations. Interactions between neurotransmitter receptors and pos ...
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 1

 TERMINÉ 

Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington’s disease (Repair-HD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

This project will tackle the huge complexity of taking stem cell therapies to clinical application for neurodegenerative disease by focusing on selective differentiation of a single neuronal phenotype (medium spiny striatal neuron: MSN) for a single well-defined disease (Huntington’s: HD). Our consortium contains expertise in all elements required to drive this technology to the point of clinical ...
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 10

 TERMINÉ 

Point-of-care tests to revolutionise the clinical management of patients infected by Hepatitis C virus (PoC-HCV)

Date du début: 1 sept. 2013, Date de fin: 31 août 2016,

Point-of-care (PoC) medical devices have the potential to revolutionise clinical practice. SMEs within our Consortium (Epistem & Biosurfit) have developed genetic and protein PoC devices to deliver on this promise. Results from these enabling technologies will be integrated using novel bioinformatics tools and algorithms (Qlucore) allowing for bed-side analysis. This integrated genetic-protein app ...
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 5

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Mechanistic Studies on Carbon Monoxide (CO)-Induced Modulation of Mitochondrial Function in Neuroinflammation (INFLAM-MITO-CO)

Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,

Neuroinflammation plays a crucial role in the development and progression of neurodegenerative diseases such as Alzheimer’s or ischemic stroke. The inflammatory response is coordinated by resident cells (microglia) that upon activation produce pro-inflammatory mediators including cytokines, chemokines and reactive oxygen species. Identification of small molecules that alleviate microglia inflammat ...
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 1

 TERMINÉ 

Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
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 16

 TERMINÉ 

Sensory perception: neural representation and modulation (ZEBRAFISH PERCEPTION)

Date du début: 1 nov. 2009, Date de fin: 30 sept. 2015,

Perception has intrigued philosophers and scientists since Aristotle ~2,300 years ago, but only recently it became technically possible to address its underlying neural mechanisms. The main scientific research approach still focuses on studying the evoked responses to a perceived sensory stimulus. However, in a state of sensory deprivation, sensory areas in the brain remain highly active. This act ...
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 1

 TERMINÉ 

Origin and function of nonrandom cortical connectivities (Nonrandom Circuits)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2014,

Recent neurophysiological experiments have revealed the existence of nonrandom connectivity patterns in the cortex of rats. These patterns consist of certain connectivity structures that appear more often than one would expect if neurons were randomly connected. An example of such departure from randomness is the prevalence of pairs of neurons reciprocally connected. Another example is the overrep ...
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 2

 TERMINÉ 

The paradoxical role of type I interferons in Hepatitis C disease pathogenesis and treatment (HCV_IMMUNOLOGY)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2014,

Hepatitis C virus (HCV) presents a significant public health problem with nearly 200 million infected people worldwide. Over the past three years, we have developed partnerships with clinicians and epidemiologists so that we can achieve better insight into immune pathogenesis of both acute and chronic HCV infection. My newly created research unit is committed to defining the complex interplay betw ...
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 1

 TERMINÉ 

Functional Biomarkers as in vitro diagnostic tools for managing patients with chronic disease (FunctionalBiomarkers)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2014,

The aim of this proposal is to establish a business plan for the development of a new class of Functional Biomarkers as in vitro diagnostic tools for managing patients with chronic disease. The proof of concept will be established by focusing on substrates of the X-prolyl dipeptidylpeptidases (DPP), a family of pleotropic enzymes that cleave the N-terminal two amino acids of proteins. There are >3 ...
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 1

 TERMINÉ 

Regulation of chromatin compaction in response to DNA damage in mammalian cells (CHROMATINDAMAGE)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2013,

"Protection of genome integrity is crucial for maintaining cell viability and preventing cancer. However, how the dynamic organisation of DNA into chromatin in the cell nucleus is orchestrated in order to allow and promote detection and repair of DNA lesions remains poorly understood. A controlled accessibility of damaged chromatin is likely critical for an efficient cellular response to DNA damag ...
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 2