9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities (ETOX)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2016,
The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This will be achieved by coordinating the efforts of specialists from academia and SMEs in the wide scope of disciplines that are required to move towards a more reliable modell ...
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30
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TERMINÉ
A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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45
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TERMINÉ
ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours (ASSET)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,
Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact ...
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20
Participants partenaires
TERMINÉ
New approaches for the targeted therapy of Non-Small Cell Lung Cancer (LUNGTARGET)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,
Lung cancer is the most common cancer fatality in Europe (335000 deaths/yr). Non-small cell lung cancer (NSCLC) consists 85% of the cases, with 5 yr survival
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10
Participants partenaires
TERMINÉ
Multifunctional Nanotechnology for selective detection and Treatment of cancer (MULTIFUN)
Date du début: 13 juin 2011, Date de fin: 12 juin 2015,
The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to p ...
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19
Participants partenaires
TERMINÉ
Molecular mechanisms of mature B cell lymphomagenesis (BCLYM)
Date du début: 1 déc. 2008, Date de fin: 30 nov. 2014,
Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an importan ...
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2
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TERMINÉ
Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2014,
Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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17
Participants partenaires
TERMINÉ
Identifying biomarkers of ageing using whole transcriptomic sequencing (EuroBATS)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,
Ageing is a fundamental biological process that defines all aspects of life, yet the understanding of the basic biological interactions leading to ageing and how genetic and environmental variation contributes to this processes are still largely unknown. We propose to use the most up to date genomic and epidemiological methodologies to shed light in some of the key questions in ageing research. We ...
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5
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TERMINÉ
GENETIC AND GENOMIC STUDY OF CELL COMPETITION IN DROSOPHILA (Supercompetitors)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
During initial stages a cell accumulating tumor-promoting mutations is usually surrounded by normal cells. Current cancer models do not incorporate this transition from a single cell to a field of cells, although it is probably critical, since the behavior of an individual tumor cell within the cell community has to be dictated by the hard-wired genetic program that controls its aberrant cell biol ...
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