10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
The current healthcare systems are built around the traditional paradigm of patients suffering from a single acute illness. They are therefore largely unprepared to face the increasing demands for health services arising from the expansion of an older population with specific medical needs related to multiple chronic disorders. As a consequence, the medical conditions of a large and growing seg ...
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27
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TERMINÉ
Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedation and analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid. However, these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatory depression. Clonidine is commonly used for sedation in PICU and recom ...
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10
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TERMINÉ
A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-FRAIL STUDY (MID-FRAIL-STUDY)
Date du début: 1 mars 2012, Date de fin: 30 avr. 2017,
The prevalence of diabetes in people ≥ 65 years approaches 25% (40% of all patients with diabetes are > 65 years). This number will increase 4-fold in people > 70 years in 2050. Diabetes results in a high personal and social health burden, and a significant public health burden in terms of rising healthcare costs. Diabetes is associated with increased functional decline in older people and may exp ...
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17
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TERMINÉ
The Sugar Code: from (bio)chemical concept to clinics (GLYCOPHARM)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
Coding of biochemical information is commonly described to be based solely on nucleotides and amino acids, whereas carbohydrates, the most abundant type of molecule in Nature, appear sidelined in this respect. That carbohydrates, as part of cellular glycoconjugates, have exceptional talents for building biochemical signals is an emerging insight, at the heart of the concept of the Sugar Code. Intu ...
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11
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TERMINÉ
EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE (EPI-FEM-CARE)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,
CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or ...
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6
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TERMINÉ
Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
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19
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TERMINÉ
Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia (NEUROSIS)
Date du début: 1 mars 2009, Date de fin: 31 août 2015,
HYPOTHESIS: Early inhalation of Budesonide (BS) reduces the absolute risk of developing bronchopulmonary dysplasia (BPD) or death in preterm infants born between 23 and 27 weeks gestational age (GA) by 10%. PRIMARY OBJECTIVE: Survival without BPD at 36 weeks GA. SECONDARY OBJECTIVES: (1) neurodevelopment at a corrected age of 18-22 months; (2) adverse treatment effects; (3) mortality at 36 weeks G ...
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15
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TERMINÉ
Cancer Genomics of the Kidney (CAGEKID)
Date du début: 1 mars 2010, Date de fin: 31 août 2014,
The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to ...
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15
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TERMINÉ
Services and Health for Elderly in Long TERm care (SHELTER)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
"One of the most relevant obstacle to assess and compare nursing home (NH) services and patients across countries relates to the fact that standardized and validated methodologies are not routinely in use in daily practice in Europe. The Minimum Data Set (MDS) is a comprehensive assessment instrument which contains a standardized set of essential clinical and functional status measures and allows ...
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8
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TERMINÉ
Increasing the PaRticipation of the ElDerly in Clinical Trials (PREDICT)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2010,
"AIM. To investigate the reasons for the exclusion of the elderly in clinical trials and to provide solutions for this problem. INTRODUCTION. Although the elderly account for high drug consumption, they are underrepresented in clinical trials. With an increasingly ageing European population it is essential to demonstrate the efficacy and safety of drugs. Clinical trials need to take into account t ...
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