3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Molecular basis of the outer membrane permeability (TRANSLOCATION)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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28
Participants partenaires
TERMINÉ
Combined Highly Active Anti-retroviral Microbicides (CHAARM)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,
This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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34
Participants partenaires
TERMINÉ
European Training Network on (+)RNA Virus Replication and Antiviral Drug Development (EUVIRNA)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,
Virus infections remain a major cause of disease, with dramatic costs in mortality, morbidity, and economic loss worldwide. There is an unmet need for potent antiviral drugs, in particular against viruses with a (+)RNA genome which include many important pathogens of humans and animals.Antiviral drug development requires a detailed understanding of virus replication and effective translation of th ...
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