4 projets européens trouvés
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TERMINÉ
The role of myelinating glia in preserving axon function (AXOGLIA)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
In the human brain, the 'bottleneck' of neuronal integrity are long axonal projections, which are often the first to degenerate in neuro-psychiatric diseases. We have discovered in mice that oligodendrocytes and Schwann cells are not only essential for the formation of myelin, but also for the functional integrity of axons and their long-term survival. However, the underlying molecular mechanisms ...
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1
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TERMINÉ
Therapeutic challenge in Leukodystrophies: Translational and ethical research towards clinical trials (LEUKOTREAT)
Date du début: 1 mars 2010, Date de fin: 31 août 2013,
Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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25
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TERMINÉ
Mechanisms of myelin biogenesis and repair (MYELIN)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
During the development of the central nervous system, specialized glia, oligodendrocytes, extend and wrap their plasma membrane around axons to form tightly packed membrane stacks that provide electrical insulation. Axonal insulation by myelin facilitates rapid nerve conduction and is essential for neuronal metabolism. Damage to the myelin sheath as it for example occurs in multiple sclerosis resu ...
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2
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TERMINÉ
Neuron-Glia Interactions in Nerve Development and Disease (NGIDD)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,
"The characteristic appearance of white matter in the nervous system results from a remarkable cellular structure called myelin. This membraneous sheath is wrapped around axons by dedicated glial cells, thereby allowing the rapid propagation of impulses along the axons. The importance of the myelin sheath is underscored by the many neurological diseases that are caused by loss or destabilization o ...
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