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12 projets européens trouvés

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 TERMINÉ 

Next generation sequencing for detection of human primary immunodeficiency syndromes characterized by impaired cytotoxic lymphocyte function (SEQ-CYTOTOX)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"Human primary immunodeficiencies affecting cytotoxic lymphocyte function are associated with high morbidity and mortality. They often present as hyperinflammatory syndromes triggered by viral infections, hematological malignancies, or systemic autoimmunity. Although recent advances have provided molecular diagnoses for some of the most severe cases, only a handful of genes have been identified an ...
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 1

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection (INFECT)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presen ...
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 16

 TERMINÉ 

Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise (PEVNET)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

"Type 1 diabetes is caused by an inflammatory process which damage insulin-producing beta-cells in the pancreas. It is one of the most common chronic diseases and its incidence is rapidly increasing. Due to its complications it causes a significant medical and economic burden to European society. A causal association between enterovirus and type 1 diabetes has become more and more likely. The aim ...
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 14

 TERMINÉ 

Molecular Mechanisms of Natural Killer cell Cytotoxicity (MOLMECHSNKTOX)

Date du début: 1 oct. 2012, Date de fin: 1 nov. 2015,

The study of immunodeficiency syndromes such as familial hemophagocytic lymphohistiocytosis (FHL) and Griscelli Syndrome type 2 (GS2) has revealed a crucial role for Munc13-4, Stx11, Munc18-2 and Rab27a – members of protein families that regulate vesicle trafficking and membrane fusion – in cytotoxic granule exocytosis. Loss-of-function mutations in these proteins result in loss of target cell kil ...
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 1

 TERMINÉ 

Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

 TERMINÉ 

Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2014,

CHAIN is a large scale integrating project aimed to effectively and durably combat new and existing anti-HIV drug resistance in clinical settings, with a special emphasis on Eastern Europe and in heavily affected resource-poor regions in Africa. This will be achieved through our pan-European network of surveillance and basic research activities, the involvement of all main actors in the field of H ...
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 28

 TERMINÉ 

Improved prediction of HIV drug resistance in different viral subtypes by bioinformatic analysis of genetic and clinical data (GlobalART)

Date du début: 1 oct. 2009, Date de fin: 30 juin 2013,

Since the advent of the HIV epidemic, more than 25 million people have died from AIDS. Antiretroviral therapy (ART) has dramatically decreased to mortality and morbidity in high income countries. However, the virus adapts rapidly during suboptimal therapy and over 200 mutations are associated with resistance to one or more drugs. Drug resistance is thus a major threat to the long-term outcome of A ...
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 1

 TERMINÉ 

Molecular mechanisms of pediatric immunodeficiency syndromes affecting natural killer cell cytotoxicity (NK in HLH)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2012,

The pediatric immunodeficiency syndromes familial haemophagocytic lymphohistiocytosis types 3 (FHL3) and 4 (FHL4), and Griscelli syndrome type 2 (GS2) are associated with loss-of-function of Munc13-4, syntaxin 11 (Stx11) and Rab27a, respectively. These proteins are members of families of membrane fusion-regulating proteins, but the precise molecular role of these proteins in granule release is inc ...
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 1

 TERMINÉ 

Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue (ADAPT)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,

"Obesity represents the major risk factor for the cardiometabolic syndrome, which is an epidemic disease that generates a severe global socio-economic burden for the public health systems. Enhanced production of proinflammatory adipocytokines by expanded adipose tissue is now considered as a key event in the pathogenesis of this syndrome. This process involves i) the systemic release of adipokines ...
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 12

 TERMINÉ 

The role of natural killer T cells in the early stages of the herpes simplex virus infection in skin (NKT in herpes)

Date du début: 1 janv. 2009, Date de fin: 31 mai 2011,

The aim of this project is to examine how the local skin microenvironment influences the generation of antiviral immune responses following herpes simplex virus type 2 (HSV-2) infection. Genital herpes, caused primarily by HSV-2, has a worldwide prevalence and is the leading cause of genital ulcers. An increasing number of clinical and epidemiological studies indicate that a recent genital HSV-2 i ...
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 1

 TERMINÉ 

Graft engineering to improve allogeneic stem cell transplantation (GIFT)

Date du début: 1 août 2008, Date de fin: 31 juil. 2010,

"Allogeneic stem cell transplantation (ASCT) is a curative therapy for various haematological malignancies. Obtaining suitably matched donors, problems with graft versus host disease (GVHD) and infection, however, limit the wider application of this therapy. Knowledge from previous studies has highlighted the need for a more effective and integrated approach to address these issues. This project e ...
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 1