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 TERMINÉ 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 TERMINÉ 

Particle-Surface Interactions in Near Field Optics: Spin-orbit Effects of Light and Optical/Casimir Forces (PSINFONI)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

PSINFONI aims to open new avenues of research in ultrafast routing and polarization synthesis of light in nanophotonics, and in the manipulation, sorting, levitation and trapping of nanoparticles, molecules, or single atoms near novel nanomaterial surfaces. To this end, we will explore the fundamentals and applications of a range of novel nanophotonic phenomena: (i) spin-orbit interactions of ligh ...
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 1

 TERMINÉ 

Mechanical control of biological function (MECHANO-CONTROL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the ...
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 7

 TERMINÉ 

Authority and Innovation in Early Franciscan Thought (c. 1220-56) (INNOVATION)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

INNOVATION anticipates a breakthrough in scholarly understanding of the medieval origins of modern Western philosophy. This breakthrough will be achieved by exposing the pioneering nature of early thirteenth-century Franciscan thought and its pivotal significance for the subsequent formation of the Western philosophical identity. The work of early Franciscans has largely been neglected in scholarl ...
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 2

 TERMINÉ 

Brain network based stratification of mental illness (STRATIFY)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcement–related be ...
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 4

 TERMINÉ 

Higgs bundles: Supersymmetric Gauge Theories and Geometry (HIGGSBNDL)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, t ...
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 2

 TERMINÉ 

Mitochondrial DNA degradation and sterile inflammation in the heart (RAMBO)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Heart failure is the leading cause of morbidity and mortality in developed countries including EU. Novel and efficient therapeutics to treat patient with heart failure have to be developed. Mitochondria are subcellular organelles that produce energy and dynamic organelles that fuse and divide. Dysregulated mitochondrial activity results in generation of free radicals which cause damage to cellular ...
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 1

 TERMINÉ 

Quantum Black Holes: A macroscopic window into the microstructure of gravity (QBH)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The thermodynamic behavior of black holes is a precious clue in unravelling the microscopic structure of quantum gravity.High precision computations of quantum black hole entropy provide a new window into the fundamental microscopic theory of gravity and its deviations from classical general relativity. Traditional methods of quantum field theory have proved to be not well-suited to perform these ...
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 1

 TERMINÉ 

Dissecting the cellular mechanics of contact inhibition of locomotion (CIL2015)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Our aim is to dissect the mechanisms of contact inhibition of locomotion (CIL), a process whereby migrating cells collide and repel each other, as it is now clear that CIL is pivotal to understanding embryogenesis and pathologies such as cancer. We have developed an in vivo model using Drosophila macrophages (hemocytes), along with novel analytical tools, to examine the contact inhibition response ...
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 1

 TERMINÉ 

Towards Early Molecular Diagnostics of Schizophrenia (SZ_TEST)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management co ...
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 9

 TERMINÉ 

Comorbid Conditions of Attention deficit / hyperactivity disorder (CoCA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, ...
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 17

 TERMINÉ 

Liaison in Scientific Training for European auditory Neuroscience (LISTEN)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

This ITN will train 10 ESRs to meet the urgent need for translation of Auditory Neuroscience into commercial and pharmaceutical products to treat hearing disorders including tinnitus. Tinnitus is the debilitating perception of imaginary sound that is often associated with hearing loss. This Liaison in Scientific Training for European auditory Neuroscience (LISTEN) is a consortium of top hearing sc ...
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 9

 TERMINÉ 

Common mechanisms and pathways in Stroke and Alzheimer's disease. (CoSTREAM)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

Common mechanisms and pathways in Stroke and Alzheimer's disease.It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstandin ...
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 11

 TERMINÉ 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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 27

 TERMINÉ 

REACH: Risk, Resilience, Ethnicity and AdolesCent Mental Health (REACH)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The overarching aim of REACH is to examine groundbreaking questions on the developmental origins of psychosis in migrant and minority ethnic populations using a highly innovative accelerated cohort study of adolescents, to be conducted in south London (UK). It has been known for over 50 years that the incidence of psychotic disorders is high in many migrant and minority ethnic groups across many c ...
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 1

 TERMINÉ 

Dark Matter and the Early Universe in the LHC Era (DARKHORIZONS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale. There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy ...
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 1

 TERMINÉ 

The values of French language and literature in the European Middle Ages (TVOF)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Two questions about linguistic identity lie at the heart of this project. What is the relation historically between language and identity in Europe? How are cognate languages demarcated from each other? Normative models of national languages helped shape Europe. Yet they did not become hegemonic until the 19th century. Indeed, they were imposed (not always successfully) on a linguistic map of Euro ...
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 1

 TERMINÉ 

Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

The objective of the ATHLOS Project is to achieve a better understanding of ageing by identifying patterns of healthy ageing pathways or trajectories, the determinants of those patterns, the critical points in time when changes in trajectories are produced, and to propose timely clinical and public health interventions to optimise healthy ageing. Moreover, a new definition of ‘old age’ based on ma ...
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 15

 TERMINÉ 

Intelligent Parkinson eaRly detectiOn Guiding NOvel Supportive InterventionS (i-PROGNOSIS)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Transition from healthy status to Parkinson’s Disease (PD) is vaguely tractable, since symptoms can be so subtle in the early stages that they go unnoticed. Lack of biomarkers and/or findings on routine MRI and CT scans, PD is left undiagnosed for years, gradually affecting the life of over 6.5 million of older adults (>55-60 yrs) worldwide, increasing the risk of their health deterioration. Epide ...
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 11

 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

DARIAH ERIC Sustainability Refined (DESIR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

Europe has a long and rich tradition as a centre for the arts and humanities. However, the digital transformation poses challenges to the arts and humanities research landscape all over the world. Responding to these challenges the Digital Research Infrastructure for Arts and Humanities (DARIAH) was launched as a pan-European network and research infrastructure. After expansion and consolidation, ...
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 18

 TERMINÉ 

PROMOTING MENTAL WELLBEING IN THE AGEING URBAN POPULATION: DETERMINANTS, POLICIES AND INTERVENTIONS IN EUROPEAN CITIES (MINDMAP)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Major depressive disorder, dementia, anxiety disorders, and substance abuse affect a substantial part of the European older population. Over 70% of Europeans reside in cities, and this percentage will increase in the next decades. Urbanization and ageing have enormous implications for public mental health. Cities pose major challenges for older citizens, but also offer opportunities for the design ...
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 14

 TERMINÉ 

Imaging the Force of Cancer (FORCE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastat ...
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 18

 TERMINÉ 

In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases (SPCCT)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The objective of the SPCCT project is to develop and validate a widely accessible, new quantitative and analytical in vivo imaging technology combining Spectral Photon Counting CT and contrast agents, to accurately and early detect, characterize and monitor neurovascular and cardiovascular disease. Spectral Photon Counting Computed Tomography (SPCCT) is a new imaging modality, currently in develop ...
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 12

 TERMINÉ 

NAture Insurance value: Assessment and Demonstration (NAIAD)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

NAIAD aims to operationalise the insurance value of ecosystems to reduce the human and economic cost of risks associated with water (floods and drought) by developing and testing - with key insurers and municipalities - the concepts, tools, applications and instruments (business models) necessary for its mainstreaming. We will do this in detail for 8 demonstration sites (DEMOs) throughout Europe a ...
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 23

 TERMINÉ 

The Developing Human Connectome Project (dHCP)

Date du début: 1 sept. 2013, Date de fin: 31 août 2019,

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectiv ...
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 4

 TERMINÉ 

SoBigData Research Infrastructure (SoBigData)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

One of the most pressing and fascinating challenges scientists face today, is understanding the complexity of our globally interconnected society. The big data arising from the digital breadcrumbs of human activities promise to let us scrutinize the ground truth of individual and collective behaviour at an unprecedented detail and scale. There is an urgent need to harness these opportunities for s ...
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 12

 TERMINÉ 

Integrating Technology into Mental Health Care Delivery in Europe (ICare)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The evidence base of Internet-based interventions in the prevention and treatment of mental health conditions has rapidly grown in the past decade. Yet many European countries (e.g., Germany, Austria, Switzerland, Great Britain, The Netherlands, Spain) have not implemented these promising approaches into health systems. Individuals with risk conditions or distinct mental health problems interested ...
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 13

 TERMINÉ 

Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients (MIROCALS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative disorder of the brain and spinal cord affecting some 40,000 individuals in Europe, causing 11,000 deaths each year. Our pioneering work on riluzole showed that it is possible to modify ALS progression but all subsequent trials of potential neuroprotective agents have failed. Thus, drug development in ALS, including trial design, patient s ...
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 12

 TERMINÉ 

Cortical circuit assembly in the developing mouse neocortex (CorCir)

Date du début: 15 août 2017, Date de fin: 14 août 2019,

The developing neocortex consists of two major neuronal subtypes–pyramidal neurons and interneurons. These two subtypes come together in the cortical plate, forming cortical circuits that can integrate and respond to external and internal stimuli. Despite recent advancement in the research on cortical networks of the developing brain, the mechanism involved in cortical circuit assembly remains rel ...
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 1

 TERMINÉ 

10/66 ten years on – monitoring and improving health expectancy by targeting frailty among older people in middle income countries (LIFE2YEARS1066)

Date du début: 1 août 2014, Date de fin: 31 juil. 2019,

"Population ageing and the transition from infectious to chronic diseases is occurring more rapidly in middle than it did in high income countries. Chronic diseases are already leading causes of death in all regions, but the focus on preventing premature mortality neglects the societal impact of the emerging epidemic on disability/dependence, particularly in older people. The PIs 12 year program o ...
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 1

 TERMINÉ 

Valuing Innovation Options and Policy Flexibility Under Uncertainty (INNOVATIONOPTIONS)

Date du début: 1 août 2016, Date de fin: 31 juil. 2019,

This proposal consists of a two-year outgoing phase (1.5 years at MIT and 6-month secondment at LUISS U. in Italy) and one-year re-integration phase at King’s College London. Following advanced innovation training, it aims to develop new ideas and frameworks based on real options theory to appraise innovation options and policy flexibility. Besides training/development and dissemination, the propo ...
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 1

 TERMINÉ 

Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg (ACTION)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, a ...
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 12

 TERMINÉ 

Lifecourse biological pathways underlying social differences in healthy ageing (LIFEPATH)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

"The dramatic differentials in healthy ageing, quality of life and life expectancy between individuals of different socioeconomic groups, is a major societal challenge facing Europe. The overarching aim of the LIFEPATH project is to understand the determinants of diverging ageing pathways among individuals belonging to different socio-economic groups. This will be achieved via an original study de ...
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 18

 TERMINÉ 

Ego-media: The impact of new media on forms and practices of self-presentation (EGO-MEDIA)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Ego-media: The impact of new media on forms and practices of self-presentationThis project aims to study the impact of new media on autobiographical narratives: an impact increasing as habits and practices of self-presentation evolve rapidly in response to constantly fast-changing technology. It will analyse the range of ways in which autobiographical forms and discursive practices are being trans ...
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 1

 TERMINÉ 

European Holocaust Research Infrastructure (EHRI)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

The European Holocaust Research Infrastructure (EHRI) project seeks to transform archival research on the Holocaust. The vision of EHRI is to integrate the data, services and expertise of existing Holocaust infrastructures on an unprecedented scale. It will allow researchers from across the globe transnational and virtual access to the integrated infrastructure, and provide them with innovative di ...
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 25

 TERMINÉ 

Tracing the global fertility chain- A new political economy of outsourced reproduction (globalfertilitychain)

Date du début: 1 mai 2017, Date de fin: 30 avr. 2019,

In a new kind of post-Fordist niche, called the reproductive bio-economy, organised around the “flow” of reproductive substances and organs, such as egg cells, embryos and wombs, women are increasingly commercialising their bodies by working as oocyte vendors, surrogate mothers or tissue providers. There is fundamental disagreement among scholars and policy makers on how the reproductive bio-econo ...
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 1

 TERMINÉ 

Pooling Activities, Resources and Tools for Heritage E-research Networking, Optimization and Synergies (PARTHENOS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

PARTHENOS aims at strengthening the cohesion of research in the broad sector of Linguistic Studies, Humanities, Cultural Heritage, History, Archaeology and related fields through a thematic cluster of European Research Infrastructures, integrating initiatives, e-infrastructures and other world-class infrastructures, and building bridges between different, although tightly, interrelated fields. PAR ...
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 19

 TERMINÉ 

MIDDLE EAST AND NORTH AFRICA REGIONAL ARCHITECTURE: MAPPING GEOPOLITICAL SHIFTS, REGIONAL ORDER AND DOMESTIC TRANSFORMATIONS (MENARA)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2019,

The ‘Middle East and North Africa Regional Architecture: mapping geopolitical shifts, regional order and domestic transformations’ -the MENARA Project- will study the geopolitical order in the making in the South and East Mediterranean Countries and the Middle East amid all deep-reaching social and political changes unfolding since 2010. The project aims at describing the main features of the regi ...
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 14

 TERMINÉ 

Revisioning the ‘Fiscal EU’: Fair, Sustainable, and Coordinated Tax and Social Policies (FairTax)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Plans for economic and monetary integration in the European Union call for fundamental changes in fiscal relations among EU member states and other countries. The 2012 Blueprint for the European Monetary Union (EMU) calls for deeper integration of fiscal policies at the level of domestic EU members, including establishing EU own-source revenues. The 2013 Social Dimension of the EMU emphasizes that ...
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 11