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Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes (BetaBat)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose me ...
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