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During its duplication, DNA, the carrier of our genetic information, is particularly vulnerable to decay, and the capacity of cells to deal with replication stress has been recognised as a major factor protecting us from genome instability and cancer. A major pathway that allows cells to overcome or bypass DNA lesions during replication is activated by posttranslational modifications of the slidin ...

"In order to succeed or even to survive, manufacturers and system integrators must be able to deliver new products with speed, diversity, high quality, and at an acceptable cost.Embedded Systems (ES) are rarely entirely conceived from scratch. Companies developing ES constantly face decisions about using and adapting existing products or product assets versus new developments. Determining the long ...